H Derakhshanian1, M H Javanbakht1, M Zarei1, E Djalali2, M Djalali3. 1. Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. 2. Department of Veterinary, Science and Research Branch of Islamic Azad University, Tehran, Iran. 3. Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: mjalali87@yahoo.com.
Abstract
INTRODUCTION AND OBJECTIVE: Previous studies have found that IGF-I may play an important role in glucose metabolism. The aim of this study is to examine the effect of vitamin D intake on the serum levels of glucose, insulin, and IGF-I in experimental diabetic rats. MATERIAL AND METHODS: A total of 24 male Sprague-Dawley rats aged six to seven months, with an average weight of 300±30g, were randomly divided into three groups (eight rats per group). The first group served as control and the other two groups received an intraperitoneal injection of 45mg/kg streptozotocin (STZ) to develop diabetes. Then groups were treated for four weeks either with placebo or vitamin D (two injections of 20,000IU/kg). RESULTS: At the end of the experiment, two injection of vitamin D were found to result in a significant increase in plasma cholecalciferol, which could improve hyperglycaemia and hypoinsulinemia in diabetic rats. HbA1c concentration had a slight and insignificant decrease following vitamin D intake. In addition, a significant decline was observed in the serum IGF-I level of STZ-treated rats in comparison to the controls, which was compensated in the vitamin D group. The serum vitamin D concentration was positively correlated to the changes in IGF-I level by Pearson test. CONCLUSIONS: These data showed for the first time that vitamin D intake could significantly improve fasting plasma glucose, insulin, and IGF-I in an experimental type 1 diabetes model.
INTRODUCTION AND OBJECTIVE: Previous studies have found that IGF-I may play an important role in glucose metabolism. The aim of this study is to examine the effect of vitamin D intake on the serum levels of glucose, insulin, and IGF-I in experimental diabeticrats. MATERIAL AND METHODS: A total of 24 male Sprague-Dawley rats aged six to seven months, with an average weight of 300±30g, were randomly divided into three groups (eight rats per group). The first group served as control and the other two groups received an intraperitoneal injection of 45mg/kg streptozotocin (STZ) to develop diabetes. Then groups were treated for four weeks either with placebo or vitamin D (two injections of 20,000IU/kg). RESULTS: At the end of the experiment, two injection of vitamin D were found to result in a significant increase in plasma cholecalciferol, which could improve hyperglycaemia and hypoinsulinemia in diabeticrats. HbA1c concentration had a slight and insignificant decrease following vitamin D intake. In addition, a significant decline was observed in the serum IGF-I level of STZ-treated rats in comparison to the controls, which was compensated in the vitamin D group. The serum vitamin D concentration was positively correlated to the changes in IGF-I level by Pearson test. CONCLUSIONS: These data showed for the first time that vitamin D intake could significantly improve fasting plasma glucose, insulin, and IGF-I in an experimental type 1 diabetes model.
Authors: Florin Muselin; Romeo T Cristina; Eugenia Dumitrescu; Alexandru O Doma; Isidora Radulov; Adina A Berbecea; Adina Horablaga; Florica E Morariu; Dan N Manea; Nicolae M Horablaga Journal: Evid Based Complement Alternat Med Date: 2022-03-11 Impact factor: 2.629
Authors: Tarek Atia; Mohammad Zahidul Iqbal; Hassan Fathy Ahmed; Hader I Sakr; M H Abdelzaher; Deaa Fekri Morsi; Mostafa E Metawee Journal: J Evid Based Integr Med Date: 2022 Jan-Dec