Sindhu R Johnson1. 1. aToronto Scleroderma Program, Department of Medicine, Toronto Western Hospital, Toronto, Ontario, CanadabMount Sinai Hospital, Toronto, CanadacInstitute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.
Abstract
PURPOSE OF REVIEW: Systemic sclerosis (SSc) subset classification criteria are a cornerstone of SSc research. Given changes in our understanding of the disease and limitations of the current criteria in the conduct of trials, the developments of new SSc subset criteria are underway. RECENT FINDINGS: This article summarizes previous iterations of SSc subset criteria, highlights current thinking about the construct underlying SSc subsets in the modern era and provides an overview of the development of new SSc subset criteria. SUMMARY: Using a combination of data-driven and expert-based innovative methodologies, a large international collaborative effort is developing new SSc subset criteria. It is anticipated that this new system of classification will shift the paradigm of how we study novel therapies in SSc.
PURPOSE OF REVIEW: Systemic sclerosis (SSc) subset classification criteria are a cornerstone of SSc research. Given changes in our understanding of the disease and limitations of the current criteria in the conduct of trials, the developments of new SSc subset criteria are underway. RECENT FINDINGS: This article summarizes previous iterations of SSc subset criteria, highlights current thinking about the construct underlying SSc subsets in the modern era and provides an overview of the development of new SSc subset criteria. SUMMARY: Using a combination of data-driven and expert-based innovative methodologies, a large international collaborative effort is developing new SSc subset criteria. It is anticipated that this new system of classification will shift the paradigm of how we study novel therapies in SSc.
Authors: D Sánchez-Cano; N Ortego-Centeno; J L Callejas; V Fonollosa Plá; R Ríos-Fernández; C Tolosa-Vilella; G Espinosa-Garriga; D Colunga-Argüelles; M V Egurbide-Arberas; M Rubio-Rivas; M Freire; J J Ríos-Blanco; L Trapiella-Martínez; M Rodríguez-Carballeira; A Marín-Ballvé; X Pla-Salas; C P Simeón-Aznar Journal: Rheumatol Int Date: 2018-01-10 Impact factor: 2.631
Authors: Zariel I Johnson; Jacqueline D Jones; Angana Mukherjee; Dianxu Ren; Carol Feghali-Bostwick; Yvette P Conley; Cecelia C Yates Journal: PLoS One Date: 2018-06-20 Impact factor: 3.240