Literature DB >> 2896064

A potassium conductance contributes to the action of somatostatin-14 to suppress ACTH secretion.

P S Pennefather1, S Heisler, J F MacDonald.   

Abstract

Somatostatin activates an inwardly rectifying potassium conductance in AtT-20 clonal corticotrophs, a cell line derived from the mouse pituitary gland. The action of somatostatin is blocked by pertussis toxin indicating that a GTP-binding protein couples the somatostatin receptor to the potassium channel. The potassium conductance is depressed by cesium. Cesium also attenuates the suppression of adrenocorticotropin hormone secretion by somatostatin suggesting that the increase in potassium conductance plays a role in this action of somatostatin.

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Year:  1988        PMID： 2896064     DOI： 10.1016/0006-8993(88)90944-4

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  12 in total

1.  Different G proteins mediate somatostatin-induced inward rectifier K+ currents in murine brain and endocrine cells.

Authors:  K Takano; J Yasufuku-Takano; T Kozasa; S Nakajima; Y Nakajima
Journal:  J Physiol       Date:  1997-08-01       Impact factor: 5.182

2.  Inwardly rectifying potassium conductances in AtT-20 clonal pituitary cells.

Authors:  A G Dousmanis; P S Pennefather
Journal:  Pflugers Arch       Date:  1992-11       Impact factor: 3.657

3.  IRK(1-3) and GIRK(1-4) inwardly rectifying K+ channel mRNAs are differentially expressed in the adult rat brain.

Authors:  C Karschin; E Dissmann; W Stühmer; A Karschin
Journal:  J Neurosci       Date:  1996-06-01       Impact factor: 6.167

4.  Purification of a putative brain somatostatin receptor.

Authors:  H T He; K Johnson; K Thermos; T Reisine
Journal:  Proc Natl Acad Sci U S A       Date:  1989-03       Impact factor: 11.205

Review 5.  Twelfth Gaddum memorial lecture. Drug receptors and the inhibition of nerve cells.

Authors:  R A North
Journal:  Br J Pharmacol       Date:  1989-09       Impact factor: 8.739

Review 6.  Pharmacology and regulation of ATP-sensitive K+ channels.

Authors:  J R de Weille; M Fosset; C Mourre; H Schmid-Antomarchi; H Bernardi; M Lazdunski
Journal:  Pflugers Arch       Date:  1989       Impact factor: 3.657

7.  Somatostatin activates an inwardly rectifying K+ conductance in freshly dispersed rat somatotrophs.

Authors:  S M Sims; B T Lussier; J Kraicer
Journal:  J Physiol       Date:  1991-09       Impact factor: 5.182

8.  Somatostatin potentiates the alpha 1-adrenergic activation of phospholipase C in striatal astrocytes through a mechanism involving arachidonic acid and glutamate.

Authors:  P Marin; J C Delumeau; M Tence; J Cordier; J Glowinski; J Premont
Journal:  Proc Natl Acad Sci U S A       Date:  1991-10-15       Impact factor: 11.205

9.  Regulation of a G protein-gated inwardly rectifying K+ channel by a Ca(2+)-independent protein kinase C.

Authors:  J L Leaney; L V Dekker; A Tinker
Journal:  J Physiol       Date:  2001-07-15       Impact factor: 5.182

10.  Heterologously expressed serotonin 1A receptors couple to muscarinic K+ channels in heart.

Authors:  A Karschin; B Y Ho; C Labarca; O Elroy-Stein; B Moss; N Davidson; H A Lester
Journal:  Proc Natl Acad Sci U S A       Date:  1991-07-01       Impact factor: 11.205
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