| Literature DB >> 28960276 |
Xuejing Wang1,2, Chengliang Wang1,2, Minghao Wu1,2, Tian Tian1,2, Tianyuan Cheng1,2, Xuan Zhang1,2, Jianye Zang1,2.
Abstract
The RNA degradosome of the pathogen Staphylococcus aureus regulates the metabolism of RNA, the expression of virulence factors, and the formation of biofilms. It is composed of the RNases J1/J2, RNase Y, CshA, PNPase, Enolase, Pfk, and a newly identified component, RnpA. However, the function and new partners of RnpA in RNA degradosome remain unknown. Here, we identified PNPase and Enolase as two novel partners for RnpA. Further studies revealed that Enolase interacts with RnpA in competition with PNPase. Enzymatic assays showed that RnpA increases Enolase activity but has no effect on PNPase. These findings provide more information about the functional relationship between RnpA and RNA degradosome.Entities:
Keywords: zzm321990Staphylococcus aureuszzm321990; Enolase; PNPase; RNA degradosome; RnpA; interaction
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Year: 2017 PMID： 28960276 DOI： 10.1002/1873-3468.12859
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124