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Literature DB >> 2895936

Comparative study of the pharmacokinetics of zuclopenthixol decanoate and fluphenazine decanoate.

A Viala¹, B Ba, A Durand, F Gouezo, N Hou, A Jørgensen.

Abstract

Seventeen outpatients were treated with depot neuroleptics, zuclopenthixol decanoate in Viscoleo or fluphenazine decanoate in sesame oil, with dosage intervals of 3 weeks. During the 4th, 6th, and 8th dosage interval blood samples were drawn in oxalated tubes. Plasma concentrations of the active neuroleptic drugs, zuclopenthixol and fluphenazine, were determined by high performance liquid chromatography. The concentrations indicated some interindividual as well as intraindividual variations. For zuclopenthixol the maximum concentration was most often seen at day 7 after injection, whereas the kinetics of the fluphenazine concentrations was more variable. There was an indication of more fluctuation in the 4th dosage interval than in the 8th dosage interval, possibly due to the fact that steady state has not yet been achieved at the 4th dosage interval.

Entities: Chemical Species

Mesh：

Substances：

Year: 1988 PMID： 2895936 DOI： 10.1007/bf00174677

Source DB: PubMed Journal: Psychopharmacology (Berl) ISSN： 0033-3158 Impact factor: 4.530

13 in total

1. Fluphenazine plasma levels in patients receiving low and conventional doses of fluphenazine decanoate.

Authors: S R Marder; E M Hawes; T Van Putten; J W Hubbard; G McKay; J Mintz; P R May; K K Midha
Journal: Psychopharmacology (Berl) Date: 1986 Impact factor: 4.530

2. Plasma fluphenazine levels by radioimmunoassay in schizophrenic patients treated with depot injections of fluphenazine decanoate.

Authors: D H Wiles; M G Gelder
Journal: Br J Clin Pharmacol Date: 1979-12 Impact factor: 4.335

3. Studies on the fate of vegetable oit after intramuscular injection into experimental animals.

Authors: O Svendsen; T Aaes-Jørgensen
Journal: Acta Pharmacol Toxicol (Copenh) Date: 1979-11

4. [Determination of cis(Z)-clopenthixol and fluphenazine in whole blood and plasma by high-performance liquid chromatography with an internal standard].

Authors: A Viala; N Hou; A Durand; B Ba; T Aaes-Jørgensen; A Jørgensen
Journal: J Pharm Belg Date: 1983 Nov-Dec

5. Specific high-performance liquid chromatographic method for estimation of the cis(Z)- and trans(E)-isomers of clopenthixol and a N-dealkyl metabolite.

Authors: T Aaes-Jørgensen
Journal: J Chromatogr Date: 1980-08-08

6. Pharmacokinetic studies on clopenthixol decanoate; a comparison with clopenthixol in dogs and rats.

Authors: T Aaes-Jorgensen; K F Overo; K P Bogeso; A Jorgensen
Journal: Acta Pharmacol Toxicol (Copenh) Date: 1977-08

7. Variation in oro-facial tardive dyskinesia during depot antipsychotic drug treatment.

Authors: T R Barnes; D H Wiles
Journal: Psychopharmacology (Berl) Date: 1983 Impact factor: 4.530

8. Serum concentrations of the isomers of clopenthixol and a metabolite in patients given cis(Z)-clopenthixol decanoate in viscoleo.

Authors: T Aaes-Jørgensen; L Kirk; E Petersen; P Danneskiold-Samsøe; A Jørgensen
Journal: Psychopharmacology (Berl) Date: 1983 Impact factor: 4.530

Comparative study of the pharmacokinetics of zuclopenthixol decanoate and fluphenazine decanoate.

1. Fluphenazine plasma levels in patients receiving low and conventional doses of fluphenazine decanoate.

2. Plasma fluphenazine levels by radioimmunoassay in schizophrenic patients treated with depot injections of fluphenazine decanoate.

3. Studies on the fate of vegetable oit after intramuscular injection into experimental animals.

4. [Determination of cis(Z)-clopenthixol and fluphenazine in whole blood and plasma by high-performance liquid chromatography with an internal standard].

5. Specific high-performance liquid chromatographic method for estimation of the cis(Z)- and trans(E)-isomers of clopenthixol and a N-dealkyl metabolite.

6. Pharmacokinetic studies on clopenthixol decanoate; a comparison with clopenthixol in dogs and rats.

7. Variation in oro-facial tardive dyskinesia during depot antipsychotic drug treatment.

8. Serum concentrations of the isomers of clopenthixol and a metabolite in patients given cis(Z)-clopenthixol decanoate in viscoleo.

9. Kinetics of fluphenazine after fluphenazine dihydrochloride, enanthate and decanoate administration to man.

10. Clopenthixol and flupenthixol depot preparations in outpatient schizophrenics. III. Serum levels.

Review 1. [Long-acting injectable antipsychotics. Overview and advice for daily routine care].

Review 2. Zuclopenthixol dihydrochloride for schizophrenia.

Review 3. Zuclopenthixol decanoate for schizophrenia and other serious mental illnesses.

Review 4. Pharmacokinetic Characteristics of Long-Acting Injectable Antipsychotics for Schizophrenia: An Overview.