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Literature DB >> 28959359

Poly(N-(2-Hydroxypropyl) Methacrylamide)-Valproic Acid Conjugates as Block Copolymer Nanocarriers.

Jawaher A Alfurhood¹, Hao Sun¹, Christopher P Kabb¹, Bryan S Tucker¹, James H Matthews², Hendrik Luesch², Brent S Sumerlin¹.

Abstract

We report nanoassemblies based on block copolymers of N-(2-hydroxypropyl) methacrylamide (HPMA) in which drug cleavage enhances the biological compatibility of the original polymer carrier by regeneration of HPMA units. Drug release via ester hydrolysis suggests this approach offers potential for stimuli-responsive drug delivery under acidic conditions.

Entities: CellLine Chemical Disease

Year: 2017 PMID： 28959359 PMCID： PMC5612619 DOI： 10.1039/C7PY00196G

Source DB: PubMed Journal: Polym Chem ISSN： 1759-9954 Impact factor: 5.582

29 in total

1. Transiently Responsive Block Copolymer Micelles Based on N-(2-Hydroxypropyl)methacrylamide Engineered with Hydrolyzable Ethylcarbonate Side Chains.

Authors: Sabah Kasmi; Benoit Louage; Lutz Nuhn; Alexandra Van Driessche; Jan Van Deun; Izet Karalic; Martijn Risseeuw; Serge Van Calenbergh; Richard Hoogenboom; Riet De Rycke; Olivier De Wever; Wim E Hennink; Bruno G De Geest
Journal: Biomacromolecules Date: 2015-12-23 Impact factor: 6.988

2. Novel drug delivery system using thermoreversible gelation polymer for malignant glioma.

Authors: Takao Arai; Tatsuhiro Joki; Masaharu Akiyama; Miyuki Agawa; Yuichi Mori; Hiroshi Yoshioka; Toshiaki Abe
Journal: J Neurooncol Date: 2006-03 Impact factor: 4.130

Review 3. Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders.

Authors: Katrina J Falkenberg; Ricky W Johnstone
Journal: Nat Rev Drug Discov Date: 2014-08-18 Impact factor: 84.694

4. Direct, controlled synthesis of the nonimmunogenic, hydrophilic polymer, poly(N-(2-hydroxypropyl)methacrylamide) via RAFT in aqueous media.

Authors: Charles W Scales; Yulia A Vasilieva; Anthony J Convertine; Andrew B Lowe; Charles L McCormick
Journal: Biomacromolecules Date: 2005 Jul-Aug Impact factor: 6.988

5. Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells.

Authors: M Göttlicher; S Minucci; P Zhu; O H Krämer; A Schimpf; S Giavara; J P Sleeman; F Lo Coco; C Nervi; P G Pelicci; T Heinzel
Journal: EMBO J Date: 2001-12-17 Impact factor: 11.598

Review 6. HDAC inhibitor-based therapies: can we interpret the code?

Authors: Maria New; Heidi Olzscha; Nicholas B La Thangue
Journal: Mol Oncol Date: 2012-10-23 Impact factor: 6.603

Review 7. Evolving anticancer drug valproic acid: insights into the mechanism and clinical studies.

Authors: Roman A Blaheta; Martin Michaelis; Pablo Hernáiz Driever; Jindrich Cinatl
Journal: Med Res Rev Date: 2005-07 Impact factor: 12.944

Review 8. pH-sensitive polymeric nanoparticles for tumor-targeting doxorubicin delivery: concept and recent advances.

Authors: Fenghua Meng; Yinan Zhong; Ru Cheng; Chao Deng; Zhiyuan Zhong
Journal: Nanomedicine (Lond) Date: 2014-03 Impact factor: 5.307

9. HPMA copolymers: origins, early developments, present, and future.

Authors: Jindrich Kopecek; Pavla Kopecková
Journal: Adv Drug Deliv Rev Date: 2009-11-14 Impact factor: 15.470

10. Histone deacetylase inhibition in the treatment of acute myeloid leukemia: the effects of valproic acid on leukemic cells, and the clinical and experimental evidence for combining valproic acid with other antileukemic agents.

Authors: Hanne Fredly; Bjørn Tore Gjertsen; Oystein Bruserud
Journal: Clin Epigenetics Date: 2013-07-30 Impact factor: 6.551

7 in total

Poly(N-(2-Hydroxypropyl) Methacrylamide)-Valproic Acid Conjugates as Block Copolymer Nanocarriers.

1. Transiently Responsive Block Copolymer Micelles Based on N-(2-Hydroxypropyl)methacrylamide Engineered with Hydrolyzable Ethylcarbonate Side Chains.

2. Novel drug delivery system using thermoreversible gelation polymer for malignant glioma.

Review 3. Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders.

4. Direct, controlled synthesis of the nonimmunogenic, hydrophilic polymer, poly(N-(2-hydroxypropyl)methacrylamide) via RAFT in aqueous media.

5. Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells.

Review 6. HDAC inhibitor-based therapies: can we interpret the code?

Review 7. Evolving anticancer drug valproic acid: insights into the mechanism and clinical studies.

Review 8. pH-sensitive polymeric nanoparticles for tumor-targeting doxorubicin delivery: concept and recent advances.

9. HPMA copolymers: origins, early developments, present, and future.

10. Histone deacetylase inhibition in the treatment of acute myeloid leukemia: the effects of valproic acid on leukemic cells, and the clinical and experimental evidence for combining valproic acid with other antileukemic agents.

Review 1. Polymeric micelles and cancer therapy: an ingenious multimodal tumor-targeted drug delivery system.

2. Histone Deacetylase Inhibitor (HDACi) Conjugated Polycaprolactone for Combination Cancer Therapy.

3. Ultrasensitive (Co)polymers Based on Poly(methacrylamide) Structure with Fining-Tunable pH Responsive Value.

Review 4. A Perspective on Reversibility in Controlled Polymerization Systems: Recent Progress and New Opportunities.

Review 5. Progress in Photo-Responsive Polypeptide Derived Nano-Assemblies.

Review 6. HPMA Copolymer-Based Nanomedicines in Controlled Drug Delivery.

Review 7. Drug Delivery with Polymeric Nanocarriers-Cellular Uptake Mechanisms.