Literature DB >> 28959072

Challenges in the Management of a Patient with Myxoedema Coma in Ghana: A Case Report.

Josephine Akpalu1, Yacoba Atiase1, Ernest Yorke1, Henrietta Fiscian2, Cecilia Kootin-Sanwu2, Albert Akpalu3.   

Abstract

Myxoedema coma is a rare life-threatening disease, and it is essential that it is managed appropriately to reduce the associated high mortality. However, in the setting where efficient healthcare delivery is hampered by inadequacies, the management of such cases may pose a significant challenge. We present the case of a middle-aged woman diagnosed with myxoedema coma and severe hyponatremia. The case report highlights some of the challenges that may be encountered during the management of myxoedema coma in similar settings and outlines the management strategies undertaken to overcome them in the absence of national guidelines. It also brings to the fore the need for clinicians to look out for clinical features suggestive of hypothyroidism particularly among high risk individuals for early diagnosis and treatment. FUNDING: None declared.

Entities:  

Keywords:  Ghana; challenges; management; myxoedema coma

Mesh:

Year:  2017        PMID: 28959072      PMCID: PMC5611947          DOI: 10.4314/gmj.v51i1.8

Source DB:  PubMed          Journal:  Ghana Med J        ISSN: 0016-9560


  16 in total

Review 1.  The pathophysiology and treatment of hyponatraemic encephalopathy: an update.

Authors:  Michael L Moritz; J Carlos Ayus
Journal:  Nephrol Dial Transplant       Date:  2003-12       Impact factor: 5.992

Review 2.  The challenge of hyponatremia.

Authors:  Horacio J Adrogué; Nicolaos E Madias
Journal:  J Am Soc Nephrol       Date:  2012-05-24       Impact factor: 10.121

3.  Acute metabolic responses in myxedema to large doses of intravenous L-thyroxine.

Authors:  E C Ridgway; J A McCammon; J Benotti; F Maloof
Journal:  Ann Intern Med       Date:  1972-10       Impact factor: 25.391

Review 4.  Myxedema coma.

Authors:  Leonard Wartofsky
Journal:  Endocrinol Metab Clin North Am       Date:  2006-12       Impact factor: 4.741

5.  Pontine and extrapontine myelinolysis: a neurologic disorder following rapid correction of hyponatremia.

Authors:  B I Karp; R Laureno
Journal:  Medicine (Baltimore)       Date:  1993-11       Impact factor: 1.889

6.  Factors associated with mortality of patients with myxoedema coma: prospective study in 11 cases treated in a single institution.

Authors:  I Rodríguez; E Fluiters; L F Pérez-Méndez; R Luna; C Páramo; R V García-Mayor
Journal:  J Endocrinol       Date:  2004-02       Impact factor: 4.286

7.  Treatment of myxoedema coma--factors associated with fatal outcome.

Authors:  B Hylander; U Rosenqvist
Journal:  Acta Endocrinol (Copenh)       Date:  1985-01

Review 8.  The treatment of hyponatremia.

Authors:  Richard H Sterns; Sagar U Nigwekar; John Kevin Hix
Journal:  Semin Nephrol       Date:  2009-05       Impact factor: 5.299

9.  Myxedema coma: a new look into an old crisis.

Authors:  Vivek Mathew; Raiz Ahmad Misgar; Sujoy Ghosh; Pradip Mukhopadhyay; Pradip Roychowdhury; Kaushik Pandit; Satinath Mukhopadhyay; Subhankar Chowdhury
Journal:  J Thyroid Res       Date:  2011-09-15

10.  Predictors of outcome in myxoedema coma: a study from a tertiary care centre.

Authors:  Pinaki Dutta; Anil Bhansali; Shriq Rashid Masoodi; Sanjay Bhadada; Navneet Sharma; Rajesh Rajput
Journal:  Crit Care       Date:  2008-01-03       Impact factor: 9.097

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