Literature DB >> 2895900

Hyperglycaemia protects against neuronal injury around experimental brain infarcts.

M Nedergaard1, A Gjedde, N H Diemer.   

Abstract

Regional glucose utilization was measured in the rat brain after occlusion of the middle cerebral artery. Normoglycaemic rat had increased glucose use in the cerebral cortex adjacent to the infarct. A fraction of the nerve cells were irreversibly injured in this region. In hyperglycaemic rats, the glucose metabolism remained normal and no nerve cell loss was found around the infarct. The findings indicate that hyperglycaemia protects against nerve cell injury in the areas next to experimental brain infarcts.

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Year:  1987        PMID： 2895900     DOI： 10.1080/01616412.1987.11739802

Source DB:  PubMed          Journal:  Neurol Res        ISSN： 0161-6412            Impact factor:   2.448


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