BACKGROUND: Eleven recommendations, based on systematic reviews, were developed for the Evidence Analysis Library's prevention of type 2 diabetes project. Two recommendations, medical nutrition therapy (MNT) and weight loss, were rated strong. OBJECTIVE: Present the basis of systematic reviews for MNT and weight loss recommendations. METHODS: Literature searches using Medline were conducted to identify studies that met eligibility criteria. The MNT literature search covered a time span of 1995 to 2012, the weight loss literature search covered 2008 to 2012 due to inclusion of a Cochrane Review meta-analysis of randomized controlled trials (RCTs) published in 2008. Eligibility criteria for inclusion of articles included original research using higher-quality study designs (ie, RCTs, case control, cohort, crossover, and nonrandomized trials) with participants aged >18 years and meeting prediabetes or metabolic syndrome diagnostic criteria. MNT was defined as individualized and delivered by a registered dietitian nutritionist or international equivalent and length of weight loss interventions was ≥3 months. MAIN OUTCOME MEASURES: Two-hour postprandial blood glucose level, glycated hemoglobin level, albumin-to-creatinine ratio (metabolic syndrome samples only), fasting blood glucose level, high-density lipoprotein cholesterol level, systolic and diastolic blood pressure, triglyceride levels, urinary albumin excretion rate (metabolic syndrome samples only), waist circumference (WC), and waist-to-hip ratio were evaluated. RESULTS: For MNT, 11 publications were included, with all 11 using an RCT study design and 10 including participants with prediabetes. A majority of publications reported significant improvements in glycemic outcomes, WC, and blood pressure. For weight loss, 28 publications were identified, with one meta-analysis (only included RCTs) and 20 publications using an RCT study design, with the meta-analysis and 10 RCTs including participants with prediabetes. A majority of publications reported significant improvements in glycemic outcomes, triglyceride level, WC, and blood pressure. CONCLUSIONS: Systematic reviews provided strong evidence that MNT and weight loss alter clinical parameters in ways that should reduce the risk of developing type 2 diabetes.
BACKGROUND: Eleven recommendations, based on systematic reviews, were developed for the Evidence Analysis Library's prevention of type 2 diabetes project. Two recommendations, medical nutrition therapy (MNT) and weight loss, were rated strong. OBJECTIVE: Present the basis of systematic reviews for MNT and weight loss recommendations. METHODS: Literature searches using Medline were conducted to identify studies that met eligibility criteria. The MNT literature search covered a time span of 1995 to 2012, the weight loss literature search covered 2008 to 2012 due to inclusion of a Cochrane Review meta-analysis of randomized controlled trials (RCTs) published in 2008. Eligibility criteria for inclusion of articles included original research using higher-quality study designs (ie, RCTs, case control, cohort, crossover, and nonrandomized trials) with participants aged >18 years and meeting prediabetes or metabolic syndrome diagnostic criteria. MNT was defined as individualized and delivered by a registered dietitian nutritionist or international equivalent and length of weight loss interventions was ≥3 months. MAIN OUTCOME MEASURES: Two-hour postprandial blood glucose level, glycated hemoglobin level, albumin-to-creatinine ratio (metabolic syndrome samples only), fasting blood glucose level, high-density lipoprotein cholesterol level, systolic and diastolic blood pressure, triglyceride levels, urinary albumin excretion rate (metabolic syndrome samples only), waist circumference (WC), and waist-to-hip ratio were evaluated. RESULTS: For MNT, 11 publications were included, with all 11 using an RCT study design and 10 including participants with prediabetes. A majority of publications reported significant improvements in glycemic outcomes, WC, and blood pressure. For weight loss, 28 publications were identified, with one meta-analysis (only included RCTs) and 20 publications using an RCT study design, with the meta-analysis and 10 RCTs including participants with prediabetes. A majority of publications reported significant improvements in glycemic outcomes, triglyceride level, WC, and blood pressure. CONCLUSIONS: Systematic reviews provided strong evidence that MNT and weight loss alter clinical parameters in ways that should reduce the risk of developing type 2 diabetes.
Authors: Sean Wharton; David C W Lau; Michael Vallis; Arya M Sharma; Laurent Biertho; Denise Campbell-Scherer; Kristi Adamo; Angela Alberga; Rhonda Bell; Normand Boulé; Elaine Boyling; Jennifer Brown; Betty Calam; Carol Clarke; Lindsay Crowshoe; Dennis Divalentino; Mary Forhan; Yoni Freedhoff; Michel Gagner; Stephen Glazer; Cindy Grand; Michael Green; Margaret Hahn; Raed Hawa; Rita Henderson; Dennis Hong; Pam Hung; Ian Janssen; Kristen Jacklin; Carlene Johnson-Stoklossa; Amy Kemp; Sara Kirk; Jennifer Kuk; Marie-France Langlois; Scott Lear; Ashley McInnes; David Macklin; Leen Naji; Priya Manjoo; Marie-Philippe Morin; Kara Nerenberg; Ian Patton; Sue Pedersen; Leticia Pereira; Helena Piccinini-Vallis; Megha Poddar; Paul Poirier; Denis Prud'homme; Ximena Ramos Salas; Christian Rueda-Clausen; Shelly Russell-Mayhew; Judy Shiau; Diana Sherifali; John Sievenpiper; Sanjeev Sockalingam; Valerie Taylor; Ellen Toth; Laurie Twells; Richard Tytus; Shahebina Walji; Leah Walker; Sonja Wicklum Journal: CMAJ Date: 2020-12-07 Impact factor: 8.262
Authors: Sean Wharton; David C W Lau; Michael Vallis; Arya M Sharma; Laurent Biertho; Denise Campbell-Scherer; Kristi Adamo; Angela Alberga; Rhonda Bell; Normand Boulé; Elaine Boyling; Jennifer Brown; Betty Calam; Carol Clarke; Lindsay Crowshoe; Dennis Divalentino; Mary Forhan; Yoni Freedhoff; Michel Gagner; Stephen Glazer; Cindy Grand; Michael Green; Margaret Hahn; Raed Hawa; Rita Henderson; Dennis Hong; Pam Hung; Ian Janssen; Kristen Jacklin; Carlene Johnson-Stoklossa; Amy Kemp; Sara Kirk; Jennifer Kuk; Marie-France Langlois; Scott Lear; Ashley McInnes; David Macklin; Leen Naji; Priya Manjoo; Marie-Philippe Morin; Kara Nerenberg; Ian Patton; Sue Pedersen; Leticia Pereira; Helena Piccinini-Vallis; Megha Poddar; Paul Poirier; Denis Prud'homme; Ximena Ramos Salas; Christian Rueda-Clausen; Shelly Russell-Mayhew; Judy Shiau; Diana Sherifali; John Sievenpiper; Sanjeev Sockalingam; Valerie Taylor; Ellen Toth; Laurie Twells; Richard Tytus; Shahebina Walji; Leah Walker; Sonja Wicklum Journal: CMAJ Date: 2020-08-04 Impact factor: 8.262
Authors: Sidra L Speaker; Radhika Rastogi; Tamara A Sussman; Bo Hu; Anita D Misra-Hebert; Michael B Rothberg Journal: J Gen Intern Med Date: 2021-01-15 Impact factor: 5.128
Authors: Enrique Albert Pérez; Marina Poveda González; Rosa María Martínez-Espinosa; Mariola D Molina Vila; Manuel Reig García-Galbis Journal: Int J Environ Res Public Health Date: 2019-09-18 Impact factor: 3.390
Authors: Alison B Evert; Michelle Dennison; Christopher D Gardner; W Timothy Garvey; Ka Hei Karen Lau; Janice MacLeod; Joanna Mitri; Raquel F Pereira; Kelly Rawlings; Shamera Robinson; Laura Saslow; Sacha Uelmen; Patricia B Urbanski; William S Yancy Journal: Diabetes Care Date: 2019-04-18 Impact factor: 19.112