| Literature DB >> 2895757 |
K Miyamoto1, M Matsuoka, N Tomita, C Suzuki, Y Sato, A Ishii, K Kitajima, H Nonaka, T Kondo, Y Hiraki.
Abstract
A B-cell line having translocations of chromosome 14 at break band q11 (the assigned locus of the alpha-chain gene of the T-cell antigen receptor) and chromosome 3 at break band p25 (the assigned locus of the c-raf-1 oncogene) was established from peripheral blood leukocytes of an adult T-cell leukemia (ATL) patient. The same chromosome 14 aberration at break band q11 and chromosome 3 aberration at break band p25 were also found in fresh T-cell leukemia cells. The B-cell line is surface immunoglobulin (sIg)+, immunoglobulin gene rearrangement+, ATL-specific antigen (ATLA)+, HTLV-1 proviral genome+, Epstein-Barr virus (EBV)-associated nuclear antigen (EBNA)+ and the EBV DNA genome+. The fresh T-leukemic cells were T-cell receptor gene rearrangement+, the HTLV-1 proviral genome+ and EBV DNA genome.Entities:
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Year: 1988 PMID： 2895757 PMCID： PMC5907761 DOI： 10.1111/j.1349-7006.1988.tb00004.x
Source DB: PubMed Journal: Jpn J Cancer Res ISSN： 0910-5050