| Literature DB >> 2895644 |
Abstract
Dibutyryl cAMP treatment of cultured rat astrocytes results in the rapid appearance of T4 to T3 conversion catalyzed by type II iodothyronine 5'deiodinase, without altering other deiodinating pathways. Induction of enzyme activity was time-dependent with a lag period of 60 min, reaching plateau levels after 6-8 hours, and required continued synthesis of mRNA and new protein. Isoproterenol also induced T4 to T3 converting activity through beta-adrenergic receptor mediated interactions. These data suggest that dibutyryl cAMP stimulated astrocytes provide an excellent model for the study of the molecular and cellular events modulating T4 to T3 conversion in the brain.Entities:
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Year: 1988 PMID： 2895644 DOI： 10.1016/s0006-291x(88)80488-1
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575