Khalaf Kridin1, Shira Zelber-Sagi2, Doron Comaneshter3, Arnon D Cohen3,4. 1. a Department of Dermatology , Rambam Health Care Campus , Haifa , Israel. 2. b School of Public Health, Faculty of Social Welfare and Health Sciences , University of Haifa , Haifa , Israel. 3. c Department of Quality Measurements and Research, Chief Physician's Office , Clalit Health Services , Tel Aviv , Israel. 4. d Siaal Research Center for Family Medicine and Primary Care, Faculty of Health Sciences , Ben-Gurion University of the Negev , Beer-Sheva , Israel.
Abstract
BACKGROUND: The coexistence of pemphigus and ulcerative colitis (UC) has been described, but the association between the two entities was not examined in the past. The primary endpoint of this study was to investigate the association between pemphigus and UC. MATERIALS AND METHODS: Patients with pemphigus were compared to age-, sex- and ethnicity-matched control subjects regarding the prevalence of UC in a cross-sectional study. Chi-square and t-tests were used for univariate analysis and a logistic regression model was used for multivariate analysis. The study was conducted utilizing the computerized database of Clalit Health Services. RESULTS: The study enrolled 1985 pemphigus patients and 9874 controls. The prevalence rate of UC was greater in patients with pemphigus than in controls (0.9% vs. 0.4%, respectively; p = .004). In a multivariate analysis pemphigus was independently associated with UC (odds ratio 1.9, 95% confidence interval 1.1-3.3, p = .034). This association was stronger among younger patients, and persisted after performing a sensitivity-analysis including only patients who were prescribed pemphigus-specific medications. CONCLUSIONS: Pemphigus is significantly associated with UC. Thus, physicians treating patients with pemphigus should be aware of this possible association. Further research is warranted to better understand the mechanism underlying this association.
BACKGROUND: The coexistence of pemphigus and ulcerative colitis (UC) has been described, but the association between the two entities was not examined in the past. The primary endpoint of this study was to investigate the association between pemphigus and UC. MATERIALS AND METHODS:Patients with pemphigus were compared to age-, sex- and ethnicity-matched control subjects regarding the prevalence of UC in a cross-sectional study. Chi-square and t-tests were used for univariate analysis and a logistic regression model was used for multivariate analysis. The study was conducted utilizing the computerized database of Clalit Health Services. RESULTS: The study enrolled 1985 pemphigus patients and 9874 controls. The prevalence rate of UC was greater in patients with pemphigus than in controls (0.9% vs. 0.4%, respectively; p = .004). In a multivariate analysis pemphigus was independently associated with UC (odds ratio 1.9, 95% confidence interval 1.1-3.3, p = .034). This association was stronger among younger patients, and persisted after performing a sensitivity-analysis including only patients who were prescribed pemphigus-specific medications. CONCLUSIONS: Pemphigus is significantly associated with UC. Thus, physicians treating patients with pemphigus should be aware of this possible association. Further research is warranted to better understand the mechanism underlying this association.
Authors: Khalaf Kridin; Virginia A Jones; Payal M Patel; Shira Zelber-Sagi; Christoph M Hammers; Giovanni Damiani; Kyle T Amber; Arnon D Cohen Journal: Immunol Res Date: 2020-11-07 Impact factor: 2.829