| Literature DB >> 2895439 |
O A Krishtal1, S V Vrublevsky.
Abstract
The inhibitory responses to glycine, taurine, beta-alanine, 2-amino-5-phosphonovaleric acid (APV) were investigated in freshly isolated neurones from medulla oblongata and hippocampus of rat using concentration clamp, voltage clamp and intracellular perfusion techniques. All substances, when applied in a steplike manner, induced a rapid increase in the chloride permeability of the cellular membrane which slowly desensitized. The responses to all substances were blocked by external strychnine. Cross-desensitization experiments demonstrated that all substances tested activate the same system of membrane receptors.Entities:
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Year: 1988 PMID： 2895439 DOI： 10.1016/0304-3940(88)90519-8
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046