| Literature DB >> 2895365 |
A Amadori1, A de Rossi, C Giaquinto, G Faulkner-Valle, F Zacchello, L Chieco-Bianchi.
Abstract
To improve on the early diagnosis of human immunodeficiency virus (HIV) infection, 37 children born to HIV-infected mothers and 22 controls were investigated for in-vitro synthesis of IgG antibody directed against HIV components. For 14 of 16 infected children western blot showed HIV-specific IgG in the supernatants of cultures of their peripheral blood lymphocyte cultures. HIV-specific IgG synthesis was detected in cultures from 4 out of 17 seropositive children aged under 15 months with no clinical or laboratory evidence of infection. No HIV-specific IgG production was observed in cultures from 4 uninfected children or 22 controls. The results show that the demonstration of in-vitro production of HIV-specific IgG may help in the early diagnosis of HIV infection in children.Entities:
Keywords: Acquired Immunodeficiency Syndrome--etiology; Age Factors; Antibodies; Biology; Child Health; Demographic Factors; Developed Countries; Diseases; Europe; Examinations And Diagnoses; Health; Hematological Effects; Hemic System; Hiv Infections; Immunity; Immunoglobulin Alterations; Immunologic Factors; Infant; Italy; Laboratory Examinations And Diagnoses; Mediterranean Countries; Physiology; Population; Population Characteristics; Pregnancy; Pregnancy Outcomes; Reproduction; Research Report; Southern Europe; Viral Diseases; Youth
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Year: 1988 PMID： 2895365 DOI： 10.1016/s0140-6736(88)91603-0
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321