Literature DB >> 28952676

Stevens - Johnson Syndrome Induced by Combination of Lamotrigine and Valproic Acid in a 9-Year-Old Boy.

K Maduemem1, A Vatca1, T O'Neill1, D Buckley1.   

Abstract

We describe the case history of a 9-year-old boy who developed Stevens-Johnson syndrome (SJS) following concomitant use of valproic acid and lamotrigine. He presented with rash and fever several weeks after introduction of lamotrigine, having been on valproic acid for seizure disorder. SJS happens to be one of the rare adverse reactions of antiepilepsy drugs (AED). Management is mainly supportive with care escalation when necessary because of the significant morbidity.

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Year:  2017        PMID: 28952676

Source DB:  PubMed          Journal:  Ir Med J        ISSN: 0332-3102


  2 in total

1.  Whole-Exome Sequencing in Patients Affected by Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Reveals New Variants Potentially Contributing to the Phenotype.

Authors:  Dora Janeth Fonseca; Adrien Morel; Kevin Llinás-Caballero; David Bolívar-Salazar; Paul Laissue
Journal:  Pharmgenomics Pers Med       Date:  2021-03-01

2.  Lamotrigine-Valproic Acid Interaction Leading to Stevens-Johnson Syndrome.

Authors:  Marta Vázquez; Cecilia Maldonado; Natalia Guevara; Andrea Rey; Pietro Fagiolino; Antonella Carozzi; Carlos Azambuja
Journal:  Case Rep Med       Date:  2018-08-29
  2 in total

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