Angel M Villalba-Rodriguez 1 , Roberto Parra-Saldivar 1 , Ishtiaq Ahmed 2 , K Karthik 3 , Yashpal S Malik 4 , Kuldeep Dhama 5 , Hafiz M N Iqbal 1 Show Affiliations »
Abstract
BACKGROUND: Several disease conditions require controlled or sustained drug release leading to complete recovery. In recent years, there has been a considerable research interest in bio-inspired biomaterials due to their potential as an alternative to the traditional synthetic counterparts. METHODS: Herein, we extensively reviewed, analyzed and compiled salient information from the authentic bibliographic databases including PubMed, Scopus, Elsevier, Springer, Bentham Science and other scientific databases. A focused review question and inclusion/exclusion criterion were adopted to appraise the quality of retrieved peerreviewed research literature. RESULTS: Research is underway around the globe on the development of 'greener' technologies with an aim to engineer novel drug delivery systems (DDS). Bio-based constructs are being engineered for target applications in different bio- and non-bio sectors of the modern world, to address growing concerns about a global dependence on nonrenewable petroleum-based resources. Therefore, in recent years, bio-inspired biomaterials have gained a considerable attention with high-value biomedical and pharmaceutical potentials. Moreover, owing to their novel characteristics like non-toxicity, biocompatibility, together with the adjustable thermo-mechanical and controllable properties, collagen, poly (lactic acid) (PLA), and chitosan-based novel constructs have raised interesting applications in many sectors of the medical world. So far, many of such bio-constructs have been implicated in drug delivery systems, tissue repair, nutritional and therapeutic uses. CONCLUSIONS: In conclusion, this review comprised of different bio-based novel materials including collagen, PLA, and chitosan and their valorization for DDS. In this review, detailed information is summarized on various geometries like microspheres, composites, and nano-films, etc. from each material. Towards the end, information is also given on their future perspectives and concluding remarks. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
BACKGROUND: Several disease conditions require controlled or sustained drug release leading to complete recovery. In recent years, there has been a considerable research interest in bio-inspired biomaterials due to their potential as an alternative to the traditional synthetic counterparts. METHODS: Herein, we extensively reviewed, analyzed and compiled salient information from the authentic bibliographic databases including PubMed, Scopus, Elsevier, Springer, Bentham Science and other scientific databases. A focused review question and inclusion/exclusion criterion were adopted to appraise the quality of retrieved peerreviewed research literature. RESULTS: Research is underway around the globe on the development of 'greener' technologies with an aim to engineer novel drug delivery systems (DDS ). Bio-based constructs are being engineered for target applications in different bio- and non-bio sectors of the modern world, to address growing concerns about a global dependence on nonrenewable petroleum-based resources. Therefore, in recent years, bio-inspired biomaterials have gained a considerable attention with high-value biomedical and pharmaceutical potentials. Moreover, owing to their novel characteristics like non-toxicity , biocompatibility, together with the adjustable thermo-mechanical and controllable properties, collagen, poly (lactic acid) (PLA), and chitosan-based novel constructs have raised interesting applications in many sectors of the medical world. So far, many of such bio-constructs have been implicated in drug delivery systems, tissue repair, nutritional and therapeutic uses. CONCLUSIONS: In conclusion, this review comprised of different bio-based novel materials including collagen, PLA, and chitosan and their valorization for DDS . In this review, detailed information is summarized on various geometries like microspheres, composites, and nano-films, etc. from each material. Towards the end, information is also given on their future perspectives and concluding remarks. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
Entities: Disease
Keywords:
Biomaterials; applications; biomedical; drug delivery systems; pharmaceutical; structural geometries
Mesh： See more »
Substances： See more »
Year: 2017
PMID： 28952433 DOI： 10.2174/1389200218666170925113132
Source DB: PubMed Journal: Curr Drug Metab ISSN： 1389-2002 Impact factor: 3.731