Nian-Sheng Tzeng1,2, Chi-Hsiang Chung3,4, Fu-Huang Lin4, Ching-Feng Huang5,6,7, Chin-Bin Yeh1,8, San-Yuan Huang1,8, Ru-Band Lu1,8,9,10,11,12,13, Hsin-An Chang1,2, Yu-Chen Kao1,14, Hui-Wen Yeh1,15,16, Wei-Shan Chiang1,17, Yu-Ching Chou4, Chang-Huei Tsao18,19, Yung-Fu Wu18, Wu-Chien Chien4,18. 1. a Department of Psychiatry , Tri-Service General Hospital, School of Medicine, National Defense Medical Center , Taipei , Taiwan , ROC. 2. b Student Counseling Center , National Defense Medical Center , Taipei , Taiwan , ROC. 3. c Taiwanese Injury Prevention and Safety Promotion Association , Taipei , Taiwan , ROC. 4. d School of Public Health , National Defense Medical Center , Taipei , Taiwan , ROC. 5. e Division of Gastroenterology, Children's Medical Center, Taipei Veterans General Hospital. 6. f School of Medicine, National Yang-Ming University. 7. g Department of Pediatrics , Tri-Service General Hospital, National Defense Medical Center , Taipei , Taiwan , ROC. 8. h Graduate Institute of Medical Sciences , National Defense Medical Center , Taipei , Taiwan , ROC. 9. i Division of Clinical Psychology , Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University , Tainan , Taiwan , ROC. 10. j Department of Psychiatry, College of Medicine , National Cheng Kung University , Tainan , Taiwan , ROC. 11. k Institute of Behavioral Medicine , College of Medicine, National Cheng Kung University , Tainan , Taiwan , ROC. 12. l Department of Psychiatry , National Cheng Kung University Hospital , Tainan , Taiwan , ROC. 13. m Center for Neuropsychiatric Research , National Health Research Institute , Zhunan, Miaoli County , Taiwan , ROC. 14. n Department of Psychiatry , Tri-Service General Hospital, Song-Shan Branch, National Defense Medical Center , Taipei , Taiwan , ROC. 15. o Institute of Bioinformatics and Systems Biology , National Chiao Tung University , Hsin-Chu , Taiwan , ROC. 16. p Department of Nursing , Tri-Service General Hospital, and School of Nursing, National Defense Medical Center , Taipei , Taiwan , ROC. 17. q Department and Institute of Mathematics , Tamkang University , New Taipei City , Taiwan , ROC. 18. r Department of Medical Research , Tri-Service General Hospital, National Defense Medical Center , Taipei , Taiwan , ROC. 19. s Department of Microbiology & Immunology , National Defense Medical Center , Taipei , Taiwan , ROC.
Abstract
OBJECTIVE: Dietary magnesium may be associated with a lower risk of dementia; however, the impact of magnesium oxide (MgO), a common laxative, on dementia has yet to be elucidated. This study aimed to investigate the association between the usage of MgO and the risk of developing dementia. METHODS: We used a dataset from the National Health Research Institute Database (NHRID) of Taiwan containing one million randomly sampled subjects to identify patients aged ≥50 years with no history of MgO usage. A total of 1547 patients who had used MgO were enrolled, along with 4641 controls who had not used the MgO propensity score matched by age, gender and comorbidity, at a ratio of 1:3. After adjusting for confounding risk factors, a Cox proportional hazards model was used to compare the risk of developing dementia during a 10 year follow-up period. RESULTS: Of the enrolled patients, 44 (2.84%) developed dementia, when compared to 199 (4.28%) in the control group. The Cox proportional hazards regression analysis revealed that the patients who had used MgO were less likely to develop dementia with a crude hazard ratio of 0.617 (95% CI, 0.445-0.856, p = .004). After adjusting for age, gender, comorbidity, geographical area and urbanization level of residence, and monthly income, the adjusted hazard ratio was 0.517 (95% CI, 0.412-0.793, p = .001). CONCLUSIONS: The patients who used MgO had a decreased risk of developing dementia. Further studies on the effects of MgO in reducing the risk of dementia are therefore warranted.
OBJECTIVE: Dietary magnesium may be associated with a lower risk of dementia; however, the impact of magnesium oxide (MgO), a common laxative, on dementia has yet to be elucidated. This study aimed to investigate the association between the usage of MgO and the risk of developing dementia. METHODS: We used a dataset from the National Health Research Institute Database (NHRID) of Taiwan containing one million randomly sampled subjects to identify patients aged ≥50 years with no history of MgO usage. A total of 1547 patients who had used MgO were enrolled, along with 4641 controls who had not used the MgO propensity score matched by age, gender and comorbidity, at a ratio of 1:3. After adjusting for confounding risk factors, a Cox proportional hazards model was used to compare the risk of developing dementia during a 10 year follow-up period. RESULTS: Of the enrolled patients, 44 (2.84%) developed dementia, when compared to 199 (4.28%) in the control group. The Cox proportional hazards regression analysis revealed that the patients who had used MgO were less likely to develop dementia with a crude hazard ratio of 0.617 (95% CI, 0.445-0.856, p = .004). After adjusting for age, gender, comorbidity, geographical area and urbanization level of residence, and monthly income, the adjusted hazard ratio was 0.517 (95% CI, 0.412-0.793, p = .001). CONCLUSIONS: The patients who used MgO had a decreased risk of developing dementia. Further studies on the effects of MgO in reducing the risk of dementia are therefore warranted.