| Literature DB >> 28951599 |
Wilaiwan Koomsiri1, Yuki Inahashi2,3, Tōru Kimura3, Kazuro Shiomi2,3, Yōko Takahashi2, Satoshi Ōmura2, Arinthip Thamchaipenet1,4, Takuji Nakashima2,3.
Abstract
Bisoxazolomycin (1), oxazolomycin A2 (2) and oxazolomycin A (3) were identified by physicochemical screening approach from a culture broth of 'Streptomyces subflavus subsp. irumaensis' AM-3603. Compound 2 is a hydrolyzed analog of 3 at the β-lactone ring, and 1 is a new dimeric analog of 2. Compounds 1 and 2 exhibited less potent antibacterial activity and cytotoxicity than 3, which might be due to lack of the β-lactone ring.Entities:
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Year: 2017 PMID： 28951599 DOI： 10.1038/ja.2017.113
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649