Jiang Liu1, Yang Bai, Aziguli Aziguli, Ya-Li Zhang. 1. Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.E-mail: 357077278@qq.com.
Abstract
OBJECTIVE: To investigate the value of neutrophil-monocyte product (NMP) combined with serum creatinine (Scr) in the assessment of the severity of acute pancreatitis (AP). METHODS: The clinical data of 120 Uighur patients with AP were retrospectively analyzed, including 104 with non-severe AP (non-SAP group) and 16 with severe AP (SAP group). The correlation of NMP combined with Scr with ICU admission and in-hospital death were analyzed. The receiver operating characteristic (ROC) curves were plotted to compare the efficiency of acute physiology and chronic health evaluation (APACHE-II), neutrophil-lymphocyte ratio (NLR) and NMP combined with Scr in determining the severity of AP. RESULTS: The levels of NMP and Scr were significantly higher in SAP group than in non-SAP group within 24 h after admission (P=0.012; P<0.001). NMP combined with Scr was positively correlated with ICU admission (r=0.489, P<0.001) and in-hospital death (r=0.383, P<0.001). No significant difference was found in the area under curve (AUC) between APACHE-II and NMP combined with Scr for determining AP severity (Z=0.38, P=0.704), but they both were superior to NLR (Z=3.10, P=0.002; Z=2.43, P=0.016). CONCLUSION: NMP combined with Scr can be a simple and effective indicator for determining the severity of AP.
OBJECTIVE: To investigate the value of neutrophil-monocyte product (NMP) combined with serum creatinine (Scr) in the assessment of the severity of acute pancreatitis (AP). METHODS: The clinical data of 120 Uighur patients with AP were retrospectively analyzed, including 104 with non-severe AP (non-SAP group) and 16 with severe AP (SAP group). The correlation of NMP combined with Scr with ICU admission and in-hospital death were analyzed. The receiver operating characteristic (ROC) curves were plotted to compare the efficiency of acute physiology and chronic health evaluation (APACHE-II), neutrophil-lymphocyte ratio (NLR) and NMP combined with Scr in determining the severity of AP. RESULTS: The levels of NMP and Scr were significantly higher in SAP group than in non-SAP group within 24 h after admission (P=0.012; P<0.001). NMP combined with Scr was positively correlated with ICU admission (r=0.489, P<0.001) and in-hospital death (r=0.383, P<0.001). No significant difference was found in the area under curve (AUC) between APACHE-II and NMP combined with Scr for determining AP severity (Z=0.38, P=0.704), but they both were superior to NLR (Z=3.10, P=0.002; Z=2.43, P=0.016). CONCLUSION: NMP combined with Scr can be a simple and effective indicator for determining the severity of AP.