Literature DB >> 2895038

Conserved 12-bp element downstream from mRNA polyadenylation sites.

M J Renan1.   

Abstract

Sequences downstream from the AATAAA motif in a number of cellular and viral transcription units have been compared. A 12-bp conserved element was identified in approximately half of the cases studied, and a consensus sequence TTGANNNTTTTTT was derived from a comparison of 74 such sequences. This element is located immediately (5-20 bp) downstream from the poly(A)-addition site in every case where this is known, and it is suggested that this element may be involved in the cleavage/polyadenylation reaction. This proposal is consistent with published studies on deletion mutants of downstream regions.

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Year:  1987        PMID： 2895038     DOI： 10.1016/0378-1119(87)90233-2

Source DB:  PubMed          Journal:  Gene        ISSN： 0378-1119            Impact factor:   3.688


  8 in total

1.  Development of a heat shock inducible expression cassette for plants: characterization of parameters for its use in transient expression assays.

Authors:  W M Ainley; J L Key
Journal:  Plant Mol Biol       Date:  1990-06       Impact factor: 4.076

2.  Bipartite structure of the downstream element of the mouse beta globin (major) poly(A) signal.

Authors:  J S Chen; J L Nordstrom
Journal:  Nucleic Acids Res       Date:  1992-05-25       Impact factor: 16.971

3.  Sequence and position requirements for uridylate-rich downstream elements of polyadenylation signals.

Authors:  Z F Chou; F Chen; J Wilusz
Journal:  Nucleic Acids Res       Date:  1994-07-11       Impact factor: 16.971

4.  Cleavage site determinants in the mammalian polyadenylation signal.

Authors:  F Chen; C C MacDonald; J Wilusz
Journal:  Nucleic Acids Res       Date:  1995-07-25       Impact factor: 16.971

5.  The puff-specific Drosophila protein Bj6, encoded by the gene no-on transient A, shows homology to RNA-binding proteins.

Authors:  H von Besser; P Schnabel; C Wieland; E Fritz; R Stanewsky; H Saumweber
Journal:  Chromosoma       Date:  1990-12       Impact factor: 4.316

Review 6.  Downstream elements of mammalian pre-mRNA polyadenylation signals: primary, secondary and higher-order structures.

Authors:  Margarita I Zarudnaya; Iryna M Kolomiets; Andriy L Potyahaylo; Dmytro M Hovorun
Journal:  Nucleic Acids Res       Date:  2003-03-01       Impact factor: 16.971

7.  Alternative polyadenylation of adeno-associated virus type 5 RNA within an internal intron is governed by both a downstream element within the intron 3' splice acceptor and an element upstream of the P41 initiation site.

Authors:  Jianming Qiu; Ramnath Nayak; David J Pintel
Journal:  J Virol       Date:  2004-01       Impact factor: 5.103

8.  Isolation and characterization of the human tyrosine aminotransferase gene.

Authors:  R Rettenmeier; E Natt; H Zentgraf; G Scherer
Journal:  Nucleic Acids Res       Date:  1990-07-11       Impact factor: 16.971
  8 in total

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