C Messina1,2, M Messina3, E Zanardi1,2. 1. Academic Unit of Medical Oncology, Policlinico Hospital San Martino-IST, Genoa. 2. Department of Internal Medicine, School of Medicine, University of Genoa, Genoa. 3. Oncology Unit, Istituto Fondazione G. Giglio, Cefalu', Italy.