Yamin Mao1,2,3, Chongwei Chi1,2,3, Fan Yang4, Jian Zhou4, Kunshan He1,2,3, Hao Li4, Xiuyuan Chen4, Jinzuo Ye1,2,3, Jun Wang4, Jie Tian1,2,3. 1. CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing, China. 2. School of Computer and Control Engineering, University of Chinese Academy of Sciences, Beijing, China. 3. Beijing Key Laboratory of Molecular Imaging, Chinese Academy of Sciences, Beijing, China. 4. Department of Thoracic Surgery, Peking University People's Hospital, Beijing, China.
Abstract
OBJECTIVES: Current surgical procedures lack high-sensitivity intraoperative imaging guidance, leading to undetected micro tumours. In vivo near-infrared (NIR) fluorescence imaging provides a powerful tool for identifying small nodules. The aim of this study was to examine our experience of using 2 different NIR devices in pulmonary resection surgery. METHODS: From August 2015 to October 2016, 36 patients with lung nodules underwent NIR fluorescence imaging thoracoscopic surgery. Two NIR devices: a D-Light P system and a SUPEREYE system were used. Patients were administered an injection of indocyanine green (ICG) through the peripheral vein 24 h preoperatively. During surgery, traditional white-light thoracoscopic exploration was performed first, followed by ICG-fluorescent-guided exploration. All detected nodules were resected and examined by a pathologist. RESULTS: Of the 36 patients, 76 nodules were resected. ICG-fluorescent imaging identified 68 nodules during in vivo exploration. The mean signal-to-background ratio of lung nodules in NIR exploration was 3.29 ± 1.81. The application of NIR devices led to the detection of 9 additional nodules that were missed using traditional detection methods (1 mm computed tomography scan and white-light thoracoscopic exploration) in 7 patients (19.4%). Four of the 9 nodules were confirmed as malignant or atypical adenomatous hyperplasia (44.4%). The other 5 nodules were confirmed as false-positive nodules. The sensitivities and positive predictive values of the ICG-fluorescent imaging for lung tumours were 88.7% and 92.6%, respectively. CONCLUSIONS: This study demonstrated the feasibility and safety of using ICG-fluorescent imaging for multiple lung nodules identification in video-assisted thoracoscopic surgery pulmonary resection. CLINICALTRIAL.GOV NUMBER: NCT02611245.
OBJECTIVES: Current surgical procedures lack high-sensitivity intraoperative imaging guidance, leading to undetected micro tumours. In vivo near-infrared (NIR) fluorescence imaging provides a powerful tool for identifying small nodules. The aim of this study was to examine our experience of using 2 different NIR devices in pulmonary resection surgery. METHODS: From August 2015 to October 2016, 36 patients with lung nodules underwent NIR fluorescence imaging thoracoscopic surgery. Two NIR devices: a D-Light P system and a SUPEREYE system were used. Patients were administered an injection of indocyanine green (ICG) through the peripheral vein 24 h preoperatively. During surgery, traditional white-light thoracoscopic exploration was performed first, followed by ICG-fluorescent-guided exploration. All detected nodules were resected and examined by a pathologist. RESULTS: Of the 36 patients, 76 nodules were resected. ICG-fluorescent imaging identified 68 nodules during in vivo exploration. The mean signal-to-background ratio of lung nodules in NIR exploration was 3.29 ± 1.81. The application of NIR devices led to the detection of 9 additional nodules that were missed using traditional detection methods (1 mm computed tomography scan and white-light thoracoscopic exploration) in 7 patients (19.4%). Four of the 9 nodules were confirmed as malignant or atypical adenomatous hyperplasia (44.4%). The other 5 nodules were confirmed as false-positive nodules. The sensitivities and positive predictive values of the ICG-fluorescent imaging for lung tumours were 88.7% and 92.6%, respectively. CONCLUSIONS: This study demonstrated the feasibility and safety of using ICG-fluorescent imaging for multiple lung nodules identification in video-assisted thoracoscopic surgery pulmonary resection. CLINICALTRIAL.GOV NUMBER: NCT02611245.
Authors: Xukai Li; Ke Xu; Renli Cen; Jinghui Deng; Zhexue Hao; Jun Liu; Hiromitsu Takizawa; Calvin S H Ng; Giuseppe Marulli; Min P Kim; Fei Cui; Jianxing He Journal: Transl Lung Cancer Res Date: 2021-05
Authors: Lisanne K A Neijenhuis; Lysanne D A N de Myunck; Okker D Bijlstra; Peter J K Kuppen; Denise E Hilling; Frank J Borm; Danielle Cohen; J Sven D Mieog; Willem H Steup; Jerry Braun; Jacobus Burggraaf; Alexander L Vahrmeijer; Merlijn Hutteman Journal: Life (Basel) Date: 2022-03-17