| Literature DB >> 2895015 |
T Sakata1, K Fukagawa, K Fujimoto, H Yoshimatsu, T Shiraishi, H Wada.
Abstract
Histamine antagonists were infused into the third ventricle of the cerebrum in rats. All the H1-, but none of the H2-antagonists tested, induced initial feeding during the early portion of the light phase when histamine level was highest. No periprandial drinking was observed. Ambulation increased during feeding. The effect on feeding was attenuated when brain histamine was normally low during the early portion of the dark phase, or was decreased by alpha-fluoromethylhistidine. Hypothalamic neuronal histamine may suppress food intake through H1-receptors, and diurnal fluctuations of food intake may mirror neuronal histamine levels.Entities:
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Year: 1988 PMID： 2895015 DOI： 10.1007/bf01941710
Source DB: PubMed Journal: Experientia ISSN： 0014-4754