Keisuke Tanaka1, Jackie Chua2,3, Robert Cincotta2,3, Emma L Ballard4, Gregory Duncombe2,5. 1. Department of Obstetrics and Gynaecology, Gold Coast University Hospital, Southport, Australia. 2. Queensland Ultrasound for Women, Spring Hill, Australia. 3. Department of Maternal Fetal Medicine, Mater Mother's Hospital, South Brisbane, Australia. 4. QIMR Berghofer Medical Research Institute, Herston, Australia. 5. Centre for Advanced Prenatal Care, Royal Brisbane and Women's Hospital, Herston, Australia.
Abstract
BACKGROUND: Fallopian tube patency testing is an essential part of infertility evaluation. Hysterosalpingo-contrast sonography (HyCoSy) has been described as reliable, well tolerated and safe compared to other modalities such as laparoscopy and a dye test or hysterosalpingography. Limited availability of the previously used contrast has led to the introduction of a foam contrast agent as an alternative. AIMS: To assess the tolerability, safety and occurrence of pregnancy post-procedure of hysterosalpingo-foam sonography (HyFoSy). MATERIALS AND METHODS: A retrospective cohort study of women who had a HyFoSy at Queensland Ultrasound for Women from March 2013 to February 2015. A questionnaire was sent to their referring doctor to identify any complications or subsequent pregnancies with or without artificial reproductive technology (ART) within six months of the HyFoSy. RESULTS: Of 200 women, four cases were abandoned due to difficulty introducing the intracervical catheter, severe discomfort or a vasovagal episode. Response from referring doctors for 155 women reported no post-procedural complication. One hundred and eleven women were followed up for at least six months. Twenty-four out of 59 women (40.7%) who had ART and 24 out of 52 women (46.2%) who did not have ART conceived. Fifty percent of women who were nulligravida at the time of investigation, found to have at least one patent fallopian tube, whose partner had a normal semen analysis, spontaneously conceived within the time of follow up. CONCLUSIONS: HyFoSy is well tolerated and safe. A preponderance of pregnancies in the first month after HyFoSy suggests that a therapeutic effect may exist.
BACKGROUND: Fallopian tube patency testing is an essential part of infertility evaluation. Hysterosalpingo-contrast sonography (HyCoSy) has been described as reliable, well tolerated and safe compared to other modalities such as laparoscopy and a dye test or hysterosalpingography. Limited availability of the previously used contrast has led to the introduction of a foam contrast agent as an alternative. AIMS: To assess the tolerability, safety and occurrence of pregnancy post-procedure of hysterosalpingo-foam sonography (HyFoSy). MATERIALS AND METHODS: A retrospective cohort study of women who had a HyFoSy at Queensland Ultrasound for Women from March 2013 to February 2015. A questionnaire was sent to their referring doctor to identify any complications or subsequent pregnancies with or without artificial reproductive technology (ART) within six months of the HyFoSy. RESULTS: Of 200 women, four cases were abandoned due to difficulty introducing the intracervical catheter, severe discomfort or a vasovagal episode. Response from referring doctors for 155 women reported no post-procedural complication. One hundred and eleven women were followed up for at least six months. Twenty-four out of 59 women (40.7%) who had ART and 24 out of 52 women (46.2%) who did not have ART conceived. Fifty percent of women who were nulligravida at the time of investigation, found to have at least one patent fallopian tube, whose partner had a normal semen analysis, spontaneously conceived within the time of follow up. CONCLUSIONS: HyFoSy is well tolerated and safe. A preponderance of pregnancies in the first month after HyFoSy suggests that a therapeutic effect may exist.
Authors: Nienke van Welie; Joukje van Rijswijk; Kim Dreyer; Machiel H A van Hooff; Jan Peter de Bruin; Harold R Verhoeve; Femke Mol; Wilhelmina M van Baal; Maaike A F Traas; Arno M van Peperstraten; Arentje P Manger; Judith Gianotten; Cornelia H de Koning; Aafke M H Koning; Neriman Bayram; David P van der Ham; Francisca P J M Vrouenraets; Michaela Kalafusova; Bob I G van de Laar; Jeroen Kaijser; Arjon F Lambeek; Wouter J Meijer; Frank J M Broekmans; Olivier Valkenburg; Lucy F van der Voet; Jeroen van Disseldorp; Marieke J Lambers; Rachel Tros; Cornelis B Lambalk; Jaap Stoker; Madelon van Wely; Patrick M M Bossuyt; Ben Willem J Mol; Velja Mijatovic Journal: Hum Reprod Date: 2022-05-03 Impact factor: 6.353