Literature DB >> 28948557

Alcoholic Cardiomyopathy: Translation Model.

S A Kryzhanovskii1, L G Kolik2, I B Tsorin2, V N Stolyaruk2, M B Vititnova2, E O Ionova2, A V Sorokina2, A D Durnev2.   

Abstract

We developed a translation model of alcoholic cardiomyopathy in rats. By the end of forced alcoholization (the rats received 10% ethanol solution as the only source of fluid for 24 weeks; mean daily ethanol consumption was 5.0-6.5 g/kg), the rats developed dilated heart failure. Echocardiography and morphometric study of the myocardium revealed a decrease in inotropic function of the heart and dilatation of the right and left ventricles. Fatty degeneration of the myocardium (pathognomonic sign of alcoholic cardiomyopathy) and decrease in electrical stability of cardiomyocytes reliably reproduce the clinical pattern of alcoholic cardiomyopathy.

Entities:  

Keywords:  alcoholic cardiomyopathy; echocardiography; morphology; sudden death; translation model

Mesh：

Substances：

Year:  2017        PMID： 28948557     DOI： 10.1007/s10517-017-3865-0

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  4 in total

1.  miR-155-5p upregulation ameliorates myocardial insulin resistance via mTOR signaling in chronic alcohol drinking rats.

Authors:  Zhaoping Li; Zhenzhen Hu; Yan Meng; Hongzhao Xu; Yali Wei; Deqiang Shen; Hao Bai; Huacai Yuan; Liyong Chen
Journal:  PeerJ       Date:  2021-04-05       Impact factor: 2.984

2.  Death-causing cardiac injuries after chronic alcohol intake identified by forensic medicine.

Authors:  Dragoş Valentin Crauciuc; Cristinel Ionel Stan; Laura Adriana Rîşcanu; Daniel Cristian Pîrvu; Diana Bulgaru-Iliescu
Journal:  Rom J Morphol Embryol       Date:  2021 Apr-Jun       Impact factor: 1.033

3.  Impact and potential mechanism of effects of chronic moderate alcohol consumption on cardiac function in aldehyde dehydrogenase 2 gene heterozygous mice.

Authors:  Qinfeng Hu; Hang Chen; Cheng Shen; Beijian Zhang; Xinyu Weng; Xiaolei Sun; Jin Liu; Zhen Dong; Kai Hu; Junbo Ge; Aijun Sun
Journal:  Alcohol Clin Exp Res       Date:  2022-04-20       Impact factor: 3.928

4.  Knockdown of lectin-like oxidized low-density lipoprotein-1 ameliorates alcoholic cardiomyopathy via inactivating the p38 mitogen-activated protein kinase pathway.

Authors:  Yifan Zhang; Ruiqi Zhang; Lan Lu; Na Zhou; Xiaoyan Lv; Xin Wang; Zhanbin Feng
Journal:  Bioengineered       Date:  2022-04       Impact factor: 6.832
  4 in total

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