Literature DB >> 28947469

Genetics of Nevirapine Metabolic Pathways at Steady State in HIV-Infected Cambodians.

Philippine Eloy1, Adrien Tessier2, Patty Fan-Havard3,4, Monidarin Chou5, Céline Verstuyft6,7,8,9, Anne-Marie Taburet7,9, David W Haas10,11, Julie Bertrand12.   

Abstract

Nevirapine is metabolized by several hepatic cytochrome P450 (CYP) isoforms to generate four primary hydroxylated metabolites: 2-hydroxynevirapine, 3-hydroxynevirapine, 8-hydroxynevirapine, and 12-hydroxynevirapine. The present study characterized associations between genetic polymorphisms and metabolite ratios in HIV-infected Cambodians. We demonstrate associations between CYP2B6 polymorphisms and metabolite ratios for both 3-hydroxynevirapine and 8-hydroxynevirapine, suggesting involvement of CYP2B6 in generating these metabolites.
Copyright © 2017 American Society for Microbiology.

Entities:  

Keywords:  genetic polymorphisms; metabolism pathways; nevirapine; population pharmacokinetics

Mesh：

Substances：

Year:  2017        PMID： 28947469      PMCID： PMC5700353          DOI： 10.1128/AAC.00733-17

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  16 in total

1.  Synthesis and characterization of DNA adducts from the HIV reverse transcriptase inhibitor nevirapine.

Authors:  Alexandra M M Antunes; Mariana P Duarte; Pedro P Santos; Gonçalo Gamboa da Costa; Thomas M Heinze; Frederick A Beland; M Matilde Marques
Journal:  Chem Res Toxicol       Date:  2008-07-03       Impact factor: 3.739

2.  Characterization of the in vitro biotransformation of the HIV-1 reverse transcriptase inhibitor nevirapine by human hepatic cytochromes P-450.

Authors:  D A Erickson; G Mather; W F Trager; R H Levy; J J Keirns
Journal:  Drug Metab Dispos       Date:  1999-12       Impact factor: 3.922

3.  Influence of CYP2B6 polymorphism on plasma and intracellular concentrations and toxicity of efavirenz and nevirapine in HIV-infected patients.

Authors:  Margalida Rotger; Sara Colombo; Hansjakob Furrer; Gabriela Bleiber; Thierry Buclin; Belle L Lee; Olivia Keiser; Jérôme Biollaz; Laurent Décosterd; Amalio Telenti
Journal:  Pharmacogenet Genomics       Date:  2005-01       Impact factor: 2.089

4.  Population pharmacokinetic-pharmacogenetic study of nevirapine in HIV-infected Cambodian patients.

Authors:  Monidarin Chou; Julie Bertrand; Olivier Segeral; Céline Verstuyft; Laurence Borand; Emmanuelle Comets; Clotilde Le Tiec; Laurent Becquemont; Vara Ouk; France Mentre; Anne-Marie Taburet
Journal:  Antimicrob Agents Chemother       Date:  2010-08-09       Impact factor: 5.191

5.  Broad but distinct role of pregnane x receptor on the expression of individual cytochrome p450s in human hepatocytes.

Authors:  Koki Kojima; Kiyoshi Nagata; Tsutomu Matsubara; Yasushi Yamazoe
Journal:  Drug Metab Pharmacokinet       Date:  2007-08       Impact factor: 3.614

6.  Impact of CYP2B6 983T>C polymorphism on non-nucleoside reverse transcriptase inhibitor plasma concentrations in HIV-infected patients.

Authors:  Christoph Wyen; Heidy Hendra; Martin Vogel; Christian Hoffmann; Heribert Knechten; Norbert H Brockmeyer; Johannes R Bogner; Jürgen Rockstroh; Stefan Esser; Hans Jaeger; Thomas Harrer; Stefan Mauss; Jan van Lunzen; Nicole Skoetz; Alexander Jetter; Christiane Groneuer; Gerd Fätkenheuer; Saye H Khoo; Deirdre Egan; David J Back; Andrew Owen
Journal:  J Antimicrob Chemother       Date:  2008-02-14       Impact factor: 5.790

7.  Pharmacokinetic assessment of nevirapine and metabolites in human immunodeficiency virus type 1-infected patients with hepatic fibrosis.

Authors:  Anna Maria Cammett; Thomas R MacGregor; Jan M Wruck; Franco Felizarta; Patrick Miailhes; Josep Mallolas; Peter J Piliero
Journal:  Antimicrob Agents Chemother       Date:  2009-07-20       Impact factor: 5.191

8.  Multiple genetic variants predict steady-state nevirapine clearance in HIV-infected Cambodians.

Authors:  Julie Bertrand; Monidarin Chou; Danielle M Richardson; Céline Verstuyft; Paul D Leger; France Mentré; Anne-Marie Taburet; David W Haas
Journal:  Pharmacogenet Genomics       Date:  2012-12       Impact factor: 2.089

9.  Demonstration of the metabolic pathway responsible for nevirapine-induced skin rash.

Authors:  Jie Chen; Baskar M Mannargudi; Ling Xu; Jack Uetrecht
Journal:  Chem Res Toxicol       Date:  2008-08-26       Impact factor: 3.739

10.  Cytochrome P450 enzymes and transporters induced by anti-human immunodeficiency virus protease inhibitors in human hepatocytes: implications for predicting clinical drug interactions.

Authors:  Vaishali Dixit; Niresh Hariparsad; Fang Li; Pankaj Desai; Kenneth E Thummel; Jashvant D Unadkat
Journal:  Drug Metab Dispos       Date:  2007-07-16       Impact factor: 3.922
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