Kaichao Wang1, Liyuan Dong2, Qinmu Fang1, Hongwei Xia1, Xinlei Hou1. 1. Department of Cardiothoracic Surgey Ward 12, Daqing Oil Field General Hospital, Daqing, Heilongjiang 163001, China. 2. Department of Gynaecology Ward 9, Daqing Oil Field General Hospital, Daqing, Heilongjiang 163001, China.
Abstract
BACKGROUND: Blood-circulating miRNAs have been reported to act as potential biomarkers in various cancers including non-small cell lung cancer (NSCLC). OBJECTIVE: This study was to assess serum miR-98 levels in NSCLC patients and explore its potential prognostic value. METHODS: The relative expression levels of miR-98 were detected by quantitative RT-PCR in the sera of 127 NSCLC patients and 60 healthy controls. RESULTS: Our results showed that serum miR-98 expression was down-regulated in NSCLC patients compared with healthy controls. Receiver operating characteristic (ROC) curve analysis suggested that serum miR-98 could be used as a potential marker in the diagnosis of NSCLC. In addition, decreased serum miR-98 was positively correlated with worse TNM stage, lymph node metastasis, as well as unfavorable overall survival. Multivariate Cox regression analysis confirmed that serum miR-98 expression was an independent prognostic factor for NSCLC. CONCLUSIONS: Therefore, serum miR-98 might be useful as a promising biomarker for prognosis prediction of NSCLC.
BACKGROUND: Blood-circulating miRNAs have been reported to act as potential biomarkers in various cancers including non-small cell lung cancer (NSCLC). OBJECTIVE: This study was to assess serum miR-98 levels in NSCLCpatients and explore its potential prognostic value. METHODS: The relative expression levels of miR-98 were detected by quantitative RT-PCR in the sera of 127 NSCLCpatients and 60 healthy controls. RESULTS: Our results showed that serum miR-98 expression was down-regulated in NSCLCpatients compared with healthy controls. Receiver operating characteristic (ROC) curve analysis suggested that serum miR-98 could be used as a potential marker in the diagnosis of NSCLC. In addition, decreased serum miR-98 was positively correlated with worse TNM stage, lymph node metastasis, as well as unfavorable overall survival. Multivariate Cox regression analysis confirmed that serum miR-98 expression was an independent prognostic factor for NSCLC. CONCLUSIONS: Therefore, serum miR-98 might be useful as a promising biomarker for prognosis prediction of NSCLC.
Authors: Simona Giglio; Cosimo De Nunzio; Roberto Cirombella; Antonella Stoppacciaro; Omar Faruq; Stefano Volinia; Gustavo Baldassarre; Andrea Tubaro; Hideshi Ishii; Carlo M Croce; Andrea Vecchione Journal: J Exp Clin Cancer Res Date: 2021-02-23