Jun Zhao1, Xuefeng Shi1, Tao Wang2, Chunhua Ying3, Shaojun He4, Yifei Chen4. 1. Department of Respiratory Medicine, Qinghai Provincial People's Hospital, Xining, China. 2. Department of Respiratory and Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, China. 3. Department of Ultrasound, Qinghai Provincial People's Hospital, Xining, China. 4. Department of Respiratory and Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
Abstract
BACKGROUND/AIMS: Accumulating studies have reported that IGF-1R (Insulin-like growth factor-1 receptor) is aberrantly expressed in NSCLC (non-small cell lung cancer), but the role of IGF-1R in NSCLC remains controversial. The present paper assessed the precise role of IGF-1R in NSCLC. METHODS: We comprehensively searched PubMed, EMBASE, and Web of Science in March 2017. Combined HRs and ORs were used to evaluate the prognostic and clinicopathological significance of IGF-1R in NSCLC respectively. RESULTS: A total of 10 eligible studies including 8 on overall survival, and 10 on clinicopathological features were identified from the databases. The results showed that high expression of IGF-1R was associated with shorter OS (overall survival) of NSCLC patients (pooled HR 1.17,95 % CI 1.00-1.36). In addition, we found that IGF-1R was related to smoking status (OR=1.82, 95 % CI=1.35-2.44) and IGF-1R tended to be highly expressed in SCC (squamous cell carcinoma) (OR=3.40 95 % CI: 1.95-5.95). CONCLUSIONS: In summary, this meta-analysis revealed that high expression of IGF-1R was associated with poor prognosis in NSCLC.
BACKGROUND/AIMS: Accumulating studies have reported that IGF-1R (Insulin-like growth factor-1 receptor) is aberrantly expressed in NSCLC (non-small cell lung cancer), but the role of IGF-1R in NSCLC remains controversial. The present paper assessed the precise role of IGF-1R in NSCLC. METHODS: We comprehensively searched PubMed, EMBASE, and Web of Science in March 2017. Combined HRs and ORs were used to evaluate the prognostic and clinicopathological significance of IGF-1R in NSCLC respectively. RESULTS: A total of 10 eligible studies including 8 on overall survival, and 10 on clinicopathological features were identified from the databases. The results showed that high expression of IGF-1R was associated with shorter OS (overall survival) of NSCLCpatients (pooled HR 1.17,95 % CI 1.00-1.36). In addition, we found that IGF-1R was related to smoking status (OR=1.82, 95 % CI=1.35-2.44) and IGF-1R tended to be highly expressed in SCC (squamous cell carcinoma) (OR=3.40 95 % CI: 1.95-5.95). CONCLUSIONS: In summary, this meta-analysis revealed that high expression of IGF-1R was associated with poor prognosis in NSCLC.
Authors: Athanasios Fountas; Shu Teng Chai; John Ayuk; Neil Gittoes; Swarupsinh Chavda; Niki Karavitaki Journal: Endocrinol Diabetes Metab Case Rep Date: 2018-03-28
Authors: Andrew J Piper; Jennifer L Clark; Jose Mercado-Matos; Asia N Matthew-Onabanjo; Chung-Cheng Hsieh; Ali Akalin; Leslie M Shaw Journal: PLoS One Date: 2019-08-08 Impact factor: 3.240