Anna-Leena Heikkinen1,2, Fanni Päkkilä1,2, Anna-Liisa Hartikainen1, Marja Vääräsmäki1,2, Tuija Männistö2,3,4,5, Eila Suvanto1,2. 1. Department of Obstetrics and Gynecology, PEDEGO Research Unit, Oulu University Hospital and University of Oulu, 90029 OYS, Finland. 2. Medical Research Center Oulu, Oulu University Hospital and University of Oulu, 90014 Oulu, Finland. 3. Northern Finland Laboratory Centre Nordlab, 90220 Oulu, Finland. 4. Department of Clinical Chemistry, University of Oulu, 90014 Oulu, Finland. 5. Department of Chronic Disease Prevention, National Institute for Health and Welfare, 90101 Oulu, Finland.
Abstract
Context and Objective: The objective of this study was to determine the effects of maternal thyroid dysfunction or antibodies during pregnancy on the cardiometabolic risk factors in children. Design, Setting, and Participants: This prospective population-based cohort study, Northern Finland Birth Cohort 1986, included all pregnancies within a year in the area. Maternal serum samples were collected before the 20th week of gestation and analyzed for thyrotropin, free T4, thyroid-peroxidase antibodies (TPO-Abs), and thyroglobulin antibodies (Tg-Abs). Cardiometabolic risk factors in children at the age of 16 years were evaluated via blood sampling and clinical examination. Data were available for 3229 to 4176 mother-child pairs. Main Outcome Measures: Waist circumference, blood pressure, lipids and lipoproteins, and insulin resistance were measured. Odds ratios (ORs) with 95% confidence intervals (CIs) of cardiometabolic risk factors in children with and without mothers with thyroid dysfunction or antibodies were calculated with logistic regression and adjusted for covariates. Results: Children of TPO-Ab-positive mothers had higher odds of metabolic syndrome (OR, 2.57; 95%, CI 1.26 to 5.25) and waist circumference indicative of metabolic syndrome (OR, 1.69; 95% CI, 1.14 to 2.50). They were also more likely to be overweight or obese (OR, 1.56; 95% CI, 1.04 to 2.34). Maternal thyroid dysfunction or Tg-Ab positivity did not associate with cardiometabolic risk factors in children. Conclusion: Metabolic syndrome, greater waist circumference, and higher body mass index were more prevalent in children of TPO-Ab-positive mothers, indicating an adverse cardiovascular health profile.
Context and Objective: The objective of this study was to determine the effects of maternal thyroid dysfunction or antibodies during pregnancy on the cardiometabolic risk factors in children. Design, Setting, and Participants: This prospective population-based cohort study, Northern Finland Birth Cohort 1986, included all pregnancies within a year in the area. Maternal serum samples were collected before the 20th week of gestation and analyzed for thyrotropin, free T4, thyroid-peroxidase antibodies (TPO-Abs), and thyroglobulin antibodies (Tg-Abs). Cardiometabolic risk factors in children at the age of 16 years were evaluated via blood sampling and clinical examination. Data were available for 3229 to 4176 mother-child pairs. Main Outcome Measures: Waist circumference, blood pressure, lipids and lipoproteins, and insulin resistance were measured. Odds ratios (ORs) with 95% confidence intervals (CIs) of cardiometabolic risk factors in children with and without mothers with thyroid dysfunction or antibodies were calculated with logistic regression and adjusted for covariates. Results:Children of TPO-Ab-positive mothers had higher odds of metabolic syndrome (OR, 2.57; 95%, CI 1.26 to 5.25) and waist circumference indicative of metabolic syndrome (OR, 1.69; 95% CI, 1.14 to 2.50). They were also more likely to be overweight or obese (OR, 1.56; 95% CI, 1.04 to 2.34). Maternal thyroid dysfunction or Tg-Ab positivity did not associate with cardiometabolic risk factors in children. Conclusion:Metabolic syndrome, greater waist circumference, and higher body mass index were more prevalent in children of TPO-Ab-positive mothers, indicating an adverse cardiovascular health profile.
Authors: Laura Lucaccioni; Monica Ficara; Valentina Cenciarelli; Alberto Berardi; Barbara Predieri; Lorenzo Iughetti Journal: Acta Biomed Date: 2020-09-15