BACKGROUND: Acute lymphoblastic leukemia (ALL) is a common cancer in children, and outcomes have greatly improved because of the refinement of multiagent chemotherapy regimens that include intensified asparaginase therapy. Asparaginase, a cornerstone of modern pediatric chemotherapy regimens for ALL and asparaginase-containing protocols, is increasingly used in adolescent and adult patients historically treated with asparaginase-free regimens. . OBJECTIVES: This article is an overview of commonly encountered asparaginase- associated toxicities and offers recommendations for treatment management. . METHODS: A literature review was conducted, reviewing asparaginase and common toxicities, specifically hypersensitivity, pancreatitis, thrombosis, hyperbilirubinemia, and hyperglycemia. . FINDINGS: The rapid identification and management of common asparaginase-associated adverse events can reduce symptom severity and limit potential interruptions to therapy, possibly improving outcomes.
BACKGROUND:Acute lymphoblastic leukemia (ALL) is a common cancer in children, and outcomes have greatly improved because of the refinement of multiagent chemotherapy regimens that include intensified asparaginase therapy. Asparaginase, a cornerstone of modern pediatric chemotherapy regimens for ALL and asparaginase-containing protocols, is increasingly used in adolescent and adult patients historically treated with asparaginase-free regimens. . OBJECTIVES: This article is an overview of commonly encountered asparaginase- associated toxicities and offers recommendations for treatment management. . METHODS: A literature review was conducted, reviewing asparaginase and common toxicities, specifically hypersensitivity, pancreatitis, thrombosis, hyperbilirubinemia, and hyperglycemia. . FINDINGS: The rapid identification and management of common asparaginase-associated adverse events can reduce symptom severity and limit potential interruptions to therapy, possibly improving outcomes.
Authors: Maaike Van Trimpont; Evelien Peeters; Yanti De Visser; Amanda M Schalk; Veerle Mondelaers; Barbara De Moerloose; Arnon Lavie; Tim Lammens; Steven Goossens; Pieter Van Vlierberghe Journal: Cancers (Basel) Date: 2022-02-11 Impact factor: 6.639