Literature DB >> 28945405

Evolution of Radical-Based Convergent Strategies for Total Syntheses of Densely Oxygenated Natural Products.

Masayuki Inoue1.   

Abstract

Densely oxygenated natural products often exhibit potent bioactivities and are expected to function as selective cellular probes and novel drug leads. Here we describe our efforts to perfect radical-based convergent strategies for generic total syntheses of these exceedingly challenging structures.

Year:  2017        PMID: 28945405     DOI: 10.1021/acs.accounts.6b00475

Source DB:  PubMed          Journal:  Acc Chem Res        ISSN: 0001-4842            Impact factor:   22.384


  2 in total

1.  A three-component coupling approach to the ACE-ring substructure of C19-diterpene alkaloids.

Authors:  Kosuke Minagawa; Daisuke Urabe; Masayuki Inoue
Journal:  J Antibiot (Tokyo)       Date:  2017-06-14       Impact factor: 2.649

2.  Forging C(sp3)-C(sp3) Bonds with Carbon-Centered Radicals in the Synthesis of Complex Molecules.

Authors:  Spencer P Pitre; Nicholas A Weires; Larry E Overman
Journal:  J Am Chem Soc       Date:  2019-01-04       Impact factor: 15.419

  2 in total

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