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Literature DB >> 28945227

Ribosomal proteins: insight into molecular roles and functions in hepatocellular carcinoma.

X Xie¹, P Guo¹, H Yu¹, Y Wang², G Chen¹.

Abstract

Ribosomes, which are important sites for the synthesis of proteins related to expression and transmission of genetic information in humans, have a complex structure and diverse functions. They consist of a variety of ribosomal proteins (RPs), ribosomal RNAs (rRNAs) and small nucleolar RNAs. Owing to the involvement of ribosomes in many important biological processes of cells, their major components, rRNAs and RPs, have an important role in human diseases, including the initiation and evolvement of malignancies. However, the main mechanisms underlying the involvement of ribosomes in cancer remain unclear. This review describes the crucial role of ribosomes in various common malignant tumors; in particular, it examines the effects of RPs, including S6, the receptor for activated C-kinase and RPS15A, on the development and progression of hepatocellular carcinoma.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2017 PMID： 28945227 DOI： 10.1038/onc.2017.343

Source DB: PubMed Journal: Oncogene ISSN： 0950-9232 Impact factor: 9.867

113 in total

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11 in total

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Journal: Hepatology Date: 2021-12-18 Impact factor: 17.425

3. Consumption of Grapes Modulates Gene Expression, Reduces Non-Alcoholic Fatty Liver Disease, and Extends Longevity in Female C57BL/6J Mice Provided with a High-Fat Western-Pattern Diet.

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Journal: Foods Date: 2022-07-05

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Authors: Yanhui Lu; Zhichao Zheng; Yunyi Yuan; Janak L Pathak; Xuechao Yang; Lijing Wang; Zhitong Ye; William C Cho; Mingtao Zeng; Lihong Wu
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5. DNA methylation signature of smoking in lung cancer is enriched for exposure signatures in newborn and adult blood.

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6. In silico survey of the central conserved regions in viroids of the Pospiviroidae family for conserved asymmetric loop structures.

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Review 7. microRNAs Mediated Regulation of the Ribosomal Proteins and its Consequences on the Global Translation of Proteins.

Authors: Abu Musa Md Talimur Reza; Yu-Guo Yuan
Journal: Cells Date: 2021-01-08 Impact factor: 6.600

8. Efficient differentiation and purification of human induced pluripotent stem cell-derived endothelial progenitor cells and expansion with the use of inhibitors of ROCK, TGF-β, and GSK3β.

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9. Identification of Key Genes and Pathways for Enchondromas by Bioinformatics Analysis.

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Journal: Biosci Rep Date: 2021-12-22 Impact factor: 3.840