Computer modeling of ischemic stroke.

The occlusion of a blood vessel in the brain causes an ischemic stroke. Current treatment relies restoration of blood flow within 3 hours. Substantial research has focused on neuroprotection to spare compromised neural tissue and extend the treatment time window. Despite success with animal models and extensive associated clinical testing, there are still no therapies of this kind. Ischemic stroke is fundamentally a multiscale phenomenon where a cascade of changes triggered by loss of blood flow involves processes at spatial scales from molecular to centimeters with damage occurring in milliseconds to days and recovery into years. Multiscale computational modeling is a technique to assist understanding of the many agents involved in these multitudinous interacting pathways to provide clues for in silico development of multi-target polypharmacy drug cocktails.