Laura Avanzino1, Andrea Ravaschio2, Giovanna Lagravinese3, Gaia Bonassi3, Giovanni Abbruzzese4, Elisa Pelosin4. 1. Department of Experimental Medicine, Section of Human Physiology and Centro Polifunzionale di Scienze Motorie, University of Genova, Genova, Italy; Ospedale Policlinico San Martino, Istituto di Ricovero e Cura a Carattere Scientifico per l'Oncologia. Electronic address: lavanzino76@gmail.com. 2. Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics and Maternal Child Health, University of Genova, Genova, Italy. 3. Department of Experimental Medicine, Section of Human Physiology and Centro Polifunzionale di Scienze Motorie, University of Genova, Genova, Italy. 4. Ospedale Policlinico San Martino, Istituto di Ricovero e Cura a Carattere Scientifico per l'Oncologia; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics and Maternal Child Health, University of Genova, Genova, Italy.
Abstract
OBJECTIVE: It is under debate whether the cerebellum plays a role in dystonia pathophysiology and in the expression of clinical phenotypes. We investigated a typical cerebellar function (anticipatory movement control) in patients with cervical dystonia (CD) with and without tremor. METHODS: Twenty patients with CD, with and without tremor, and 17 healthy controls were required to catch balls of different load: 15 trials with a light ball, 25 trials with a heavy ball (adaptation) and 15 trials with a light ball (post-adaptation). Arm movements were recorded using a motion capture system. We evaluated: (i) the anticipatory adjustment (just before the impact); (ii) the extent and rate of the adaptation (at the impact) and (iii) the aftereffect in the post-adaptation phase. RESULTS: The anticipatory adjustment was reduced during adaptation in CD patients with tremor respect to CD patients without tremor and controls. The extent and rate of adaptation and the aftereffect in the post-adaptation phase were smaller in CD with tremor than in controls and CD without tremor. CONCLUSION: Patients with cervical dystonia and tremor display an abnormal predictive movement control. SIGNIFICANCE: Our findings point to a possible role of cerebellum in the expression of a clinical phenotype in dystonia.
OBJECTIVE: It is under debate whether the cerebellum plays a role in dystonia pathophysiology and in the expression of clinical phenotypes. We investigated a typical cerebellar function (anticipatory movement control) in patients with cervical dystonia (CD) with and without tremor. METHODS: Twenty patients with CD, with and without tremor, and 17 healthy controls were required to catch balls of different load: 15 trials with a light ball, 25 trials with a heavy ball (adaptation) and 15 trials with a light ball (post-adaptation). Arm movements were recorded using a motion capture system. We evaluated: (i) the anticipatory adjustment (just before the impact); (ii) the extent and rate of the adaptation (at the impact) and (iii) the aftereffect in the post-adaptation phase. RESULTS: The anticipatory adjustment was reduced during adaptation in CDpatients with tremor respect to CDpatients without tremor and controls. The extent and rate of adaptation and the aftereffect in the post-adaptation phase were smaller in CD with tremor than in controls and CD without tremor. CONCLUSION:Patients with cervical dystonia and tremor display an abnormal predictive movement control. SIGNIFICANCE: Our findings point to a possible role of cerebellum in the expression of a clinical phenotype in dystonia.
Authors: Martin Bareš; Richard Apps; Laura Avanzino; Assaf Breska; Egidio D'Angelo; Pavel Filip; Marcus Gerwig; Richard B Ivry; Charlotte L Lawrenson; Elan D Louis; Nicholas A Lusk; Mario Manto; Warren H Meck; Hiroshi Mitoma; Elijah A Petter Journal: Cerebellum Date: 2019-04 Impact factor: 3.847
Authors: Ruo-Yah Lai; Darya Tomishon; Karla P Figueroa; Stefan M Pulst; Susan Perlman; George Wilmot; Christopher M Gomez; Jeremy D Schmahmann; Henry Paulson; Vikram G Shakkottai; Sarah H Ying; Theresa Zesiewicz; Khalaf Bushara; Michael Geschwind; Guangbin Xia; S H Subramony; Tetsuo Ashizawa; Sheng-Han Kuo Journal: Cerebellum Date: 2019-06 Impact factor: 3.847
Authors: Daniel T Corp; Juho Joutsa; R Ryan Darby; Cathérine C S Delnooz; Bart P C van de Warrenburg; Danielle Cooke; Cecília N Prudente; Jianxun Ren; Martin M Reich; Amit Batla; Kailash P Bhatia; Hyder A Jinnah; Hesheng Liu; Michael D Fox Journal: Brain Date: 2019-06-01 Impact factor: 13.501