Gladys E Maestre1, Luis J Mena2, Jesus D Melgarejo3, Daniel C Aguirre-Acevedo4, Gloria Pino-Ramírez5, Milady Urribarrí5, Inara J Chacon3, Carlos A Chávez3, Luis Falque-Madrid3, Ciro A Gaona3, Joseph D Terwilliger6, Joseph H Lee7, Nikolaos Scarmeas8. 1. Laboratory of Neurosciences, Institute of Biological Research, Faculty of Medicine, University of Zulia, Maracaibo, Venezuela; Department of Biomedical Sciences, Division of Neuroscience, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA. Electronic address: gladys.maestre@utrgv.edu. 2. Academic Unit of Computing, Polytechnic University of Sinaloa, Mazatlán, México. 3. Laboratory of Neurosciences, Institute of Biological Research, Faculty of Medicine, University of Zulia, Maracaibo, Venezuela. 4. Medical Research Institute, School of Medicine, Medical Research Institute, University of Antioquia, Medellín, Colombia. 5. Laboratory of Neurosciences, Institute of Biological Research, Faculty of Medicine, University of Zulia, Maracaibo, Venezuela; Center for Psychological Research (CINVEPSI), Department of Applied Psychology, School of Psychology, Rafael Urdaneta University, Maracaibo, Venezuela. 6. Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA; Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA; Department of Genetics and Development, Columbia University, New York, NY, USA; Department of Psychiatry, Columbia University, New York, NY, USA; Division of Medical Genetics, New York State Psychiatric Institute, New York, NY, USA; Division of Public Health Genomics, National Institute for Health and Welfare, Helsinki, Finland. 7. Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA; Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA; Department of Epidemiology, School of Public Health, Columbia University, New York, NY, USA. 8. Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA; Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA; Department of Social Medicine, Psychiatry and Neurology, National and Kapodestrian University of Athens, Athens, Greece.
Abstract
INTRODUCTION: There are few longitudinal studies of dementia in developing countries. We used longitudinal data from the Maracaibo Aging Study to accurately determine the age- and sex-specific incidence of dementia in elderly Latin Americans. METHODS: The Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition, Text Revision) was used to diagnose dementia, which was classified as Alzheimer's disease, vascular dementia, or other. Age- and sex-specific incidence was estimated as the number of new cases of dementia divided by person-years (p-y) of follow-up. RESULTS: The incidence of all dementia diagnoses was 9.10 per 1000 p-y (95% confidence interval [CI] 7.13-11.44; 8026 total p-y), 5.18 for Alzheimer's disease (95% CI 3.72-7.03; 7916 total p-y), and 3.35 for vascular dementia (95% CI 2.19-4.91; 7757 total p-y). DISCUSSION: Among Maracaibo Aging Study participants younger than 65 years, the incidence of dementia was higher than that of US Whites. Among individuals older than 65 years, the incidence was comparable to the mean of previous incidence estimates for other populations worldwide.
INTRODUCTION: There are few longitudinal studies of dementia in developing countries. We used longitudinal data from the Maracaibo Aging Study to accurately determine the age- and sex-specific incidence of dementia in elderly Latin Americans. METHODS: The Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition, Text Revision) was used to diagnose dementia, which was classified as Alzheimer's disease, vascular dementia, or other. Age- and sex-specific incidence was estimated as the number of new cases of dementia divided by person-years (p-y) of follow-up. RESULTS: The incidence of all dementia diagnoses was 9.10 per 1000 p-y (95% confidence interval [CI] 7.13-11.44; 8026 total p-y), 5.18 for Alzheimer's disease (95% CI 3.72-7.03; 7916 total p-y), and 3.35 for vascular dementia (95% CI 2.19-4.91; 7757 total p-y). DISCUSSION: Among Maracaibo Aging Study participants younger than 65 years, the incidence of dementia was higher than that of US Whites. Among individuals older than 65 years, the incidence was comparable to the mean of previous incidence estimates for other populations worldwide.
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