Franco De Crescenzo1, Giulia Serra2, Francesco Maisto1, Mai Uchida3, Hilary Woodworth4, Maria Pia Casini5, Ross J Baldessarini6, Stefano Vicari5. 1. Institute of Psychiatry and Psychology, Catholic University of the Sacred Heart, Rome. 2. Child Psychiatry Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Harvard Medical School, Boston, MA, and International Consortium for Mood and Psychotic Disorders Research, Mailman Research Center, McLean Hospital, Belmont, MA. Electronic address: giuliaserra@gmail.com. 3. Harvard Medical School and Pediatric Psychopharmacology Program, Massachusetts General Hospital, Boston. 4. Pediatric Psychopharmacology Program, Massachusetts General Hospital. 5. Child Psychiatry Unit, Bambino Gesù Children's Hospital, IRCCS, Rome. 6. Harvard Medical School and International Consortium for Mood and Psychotic Disorders Research, Mailman Research Center, McLean Hospital.
Abstract
OBJECTIVE: Suicide attempts are prevalent in association with major mood disorders, and risk is greater with bipolar disorder (BD) than major depressive disorder (MDD) in adults. There may be similar relationships in juvenile mood disorders, but the evidence has not been compiled systematically and quantitatively. METHOD: We searched for reports of studies comparing rates of suicide attempts in children or adolescents diagnosed with BD or MDD, and applied random-effects meta-analysis. RESULTS: In 6 reports from 1995 to 2017, with 2,303 participants diagnosed with mood disorder from the United States and South Korea, aged 3 to 18 years, rates of suicide attempts differed significantly by diagnosis: BD (31.5%) > MDD (20.5%) > hypomania or mania-only (8.49%). Risk of suicide attempts differed (BD > MDD) highly significantly by meta-analysis (odds ratio [OR] = 1.71, CI = 1.33-2.20, p < .0001), and was very similar if a study with attempts and suicidal ideation was excluded (OR = 1.64, CI = 1.26-2.15, p < .0001). CONCLUSION: Risk of suicide attempts in juvenile mood disorder patients ranked: BD > MDD >> hypomania or mania-only >> juvenile general population.
OBJECTIVE: Suicide attempts are prevalent in association with major mood disorders, and risk is greater with bipolar disorder (BD) than major depressive disorder (MDD) in adults. There may be similar relationships in juvenile mood disorders, but the evidence has not been compiled systematically and quantitatively. METHOD: We searched for reports of studies comparing rates of suicide attempts in children or adolescents diagnosed with BD or MDD, and applied random-effects meta-analysis. RESULTS: In 6 reports from 1995 to 2017, with 2,303 participants diagnosed with mood disorder from the United States and South Korea, aged 3 to 18 years, rates of suicide attempts differed significantly by diagnosis: BD (31.5%) > MDD (20.5%) > hypomania or mania-only (8.49%). Risk of suicide attempts differed (BD > MDD) highly significantly by meta-analysis (odds ratio [OR] = 1.71, CI = 1.33-2.20, p < .0001), and was very similar if a study with attempts and suicidal ideation was excluded (OR = 1.64, CI = 1.26-2.15, p < .0001). CONCLUSION: Risk of suicide attempts in juvenile mood disorderpatients ranked: BD > MDD >> hypomania or mania-only >> juvenile general population.
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