Ana Sofia França Cruz Ximenes1, Pedro Pires2, Heron Werner3, Patricia Mello Jungmann4, Epitácio Leite Rolim Filho5, Etiene Pedrosa Andrade6, Roberto Souza Lemos6, Alberto Borges Peixoto7, Mohammad Zare Mehrjardi8,9, Gabriele Tonni10, Edward Araujo Júnior11. 1. a Department of Radiology , Pernambuco University (UPE) , Recife , Brazil. 2. b Department of Maternal and Child , Pernambuco University (UPE) , Recife , Brazil. 3. c Department of Radiology , Clínica de Diagnóstico por Imagem (CDPI) , Rio de Janeiro , Brazil. 4. d Department of Pathology , Pernambuco University (UPE) , Recife , Brazil. 5. e Department of Surgery , Federal University of Pernambuco (UFPE) , Recife , Brazil. 6. f Radiology Unit , Getúlio Vargas Hospital , Recife , Brazil. 7. g Mário Palmério University Hospital, University of Uberaba (UNIUBE) , Uberaba , Brazil. 8. h Department of Radiology, Shohada Tajrish Hospital, School of Medicine , Shahid Beheshti University of Medical Sciences , Tehran , Iran. 9. i Section of Pediatric Imaging, Division of Clinical Research , Climax Radiology Education Foundation , Tehran , Iran. 10. j Department of Obstetrics and Gynecology , Guastalla Civil Hospital, AUSL Reggio Emilia , Italy. 11. k Department of Obstetrics, Paulista School of Medicine , Federal University of São Paulo (EPM-UNIFESP) , São Paulo , Brazil.
Abstract
OBJECTIVE: The objective of this study is to determine the main neuroimaging findings of microcephalic newborns with possible Zika virus (ZIKV) intrauterine infection using transfontanellar cranial ultrasound. METHODS: We performed a retrospective study to describe the main neuroimaging findings in newborns with microcephaly and possible association with congenital ZIKV infection. Microcephaly was defined in the postnatal period using transfontanellar cranial examination which was performed using both two- (2D) and three-dimensional (3D) ultrasound. RESULTS: One hundred and fifty newborns with microcephaly were identified during the study period. The mean ± (standard deviation - SD) of cephalic perimeter was 28.5 ± 4.2 cm (range, 25-38 cm). Transfontanellar neuroimaging patterns detected cerebral calcifications, neuronal migrational abnormalities, dysgenesis of the corpus callosum, and cerebellar atrophy in 34.9%, 31.1%, 26%, and 16.2%, respectively. Hydrocephalus was seen in 28% of overall newborns. A history of maculopapular rash was present in almost half of the mothers (46.1%). CONCLUSION: Neuroimaging patterns by means of transfontanellar ultrasound are accurate and diagnostic investigations of brain pathology in newborns affected by microcephaly and possible intrauterine ZIKV infection.
OBJECTIVE: The objective of this study is to determine the main neuroimaging findings of microcephalic newborns with possible Zika virus (ZIKV) intrauterine infection using transfontanellar cranial ultrasound. METHODS: We performed a retrospective study to describe the main neuroimaging findings in newborns with microcephaly and possible association with congenital ZIKV infection. Microcephaly was defined in the postnatal period using transfontanellar cranial examination which was performed using both two- (2D) and three-dimensional (3D) ultrasound. RESULTS: One hundred and fifty newborns with microcephaly were identified during the study period. The mean ± (standard deviation - SD) of cephalic perimeter was 28.5 ± 4.2 cm (range, 25-38 cm). Transfontanellar neuroimaging patterns detected cerebral calcifications, neuronal migrational abnormalities, dysgenesis of the corpus callosum, and cerebellar atrophy in 34.9%, 31.1%, 26%, and 16.2%, respectively. Hydrocephalus was seen in 28% of overall newborns. A history of maculopapular rash was present in almost half of the mothers (46.1%). CONCLUSION: Neuroimaging patterns by means of transfontanellar ultrasound are accurate and diagnostic investigations of brain pathology in newborns affected by microcephaly and possible intrauterine ZIKV infection.
Authors: Maria Conceição N Costa; Luciana Lobato Cardim; Maria Gloria Teixeira; Mauricio L Barreto; Rita de Cassia Oliveira de Carvalho-Sauer; Florisneide R Barreto; Martha Suely Itaparica Carvalho; Wanderson K Oliveira; Giovanny V A França; Eduardo Hage Carmo; Roberto F S Andrade; Moreno S Rodrigues; Rafael V Veiga; Juliane F Oliveira; Qeren H R F Fernandes; Larissa C Costa; Giovanini E Coelho; Enny S Paixao Journal: Viruses Date: 2020-10-29 Impact factor: 5.048
Authors: Leão Vhp; M M Aragão; R S Pinho; A N Hazin; A R Paciorkowski; A C Penalva de Oliveira; Marcelo Rodrigues Masruha Journal: Curr Neurol Neurosci Rep Date: 2020-09-03 Impact factor: 5.081