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Literature DB >> 28941877

Arc - An endogenous neuronal retrovirus?

Abstract

The neuronal gene Arc is essential for long-lasting information storage in the mammalian brain and has been implicated in various neurological disorders. However, little is known about Arc's evolutionary origins. Recent studies suggest that mammalian Arc originated from a vertebrate lineage of Ty3/gypsy retrotransposons, which are also ancestral to retroviruses. In particular, Arc contains homology to the Gag polyprotein that forms the viral capsid and is essential for viral infectivity. This surprising connection raises the intriguing possibility that Arc may share molecular characteristics of retroviruses.

Entities: Chemical Disease Gene Species

Keywords: Arc; Evolution; Gag; HIV; Retrotransposon; Retrovirus; Synaptic plasticity

Mesh：

Substances：

Year: 2017 PMID： 28941877 PMCID： PMC5862763 DOI： 10.1016/j.semcdb.2017.09.029

Source DB: PubMed Journal: Semin Cell Dev Biol ISSN： 1084-9521 Impact factor: 7.727

71 in total

Review 1. New views of Arc, a master regulator of synaptic plasticity.

Authors: Jason D Shepherd; Mark F Bear
Journal: Nat Neurosci Date: 2011-01-30 Impact factor: 24.884

2. Arc: building a bridge from viruses to memory.

Authors: Cameron Day; Jason D Shepherd
Journal: Biochem J Date: 2015-07-01 Impact factor: 3.857

3. Deletion of Peg10, an imprinted gene acquired from a retrotransposon, causes early embryonic lethality.

Authors: Ryuichi Ono; Kenji Nakamura; Kimiko Inoue; Mie Naruse; Takako Usami; Noriko Wakisaka-Saito; Toshiaki Hino; Rika Suzuki-Migishima; Narumi Ogonuki; Hiromi Miki; Takashi Kohda; Atsuo Ogura; Minesuke Yokoyama; Tomoko Kaneko-Ishino; Fumitoshi Ishino
Journal: Nat Genet Date: 2005-12-11 Impact factor: 38.330

4. Interaction of HIV-1 Gag with the clathrin-associated adaptor AP-2.

Authors: Melissa Batonick; Manuel Favre; Michael Boge; Paul Spearman; Stefan Höning; Markus Thali
Journal: Virology Date: 2005-09-01 Impact factor: 3.616

5. Internal initiation of translation of five dendritically localized neuronal mRNAs.

Authors: J K Pinkstaff; S A Chappell; V P Mauro; G M Edelman; L A Krushel
Journal: Proc Natl Acad Sci U S A Date: 2001-02-20 Impact factor: 11.205

Review 6. Regulatory activities of transposable elements: from conflicts to benefits.

Authors: Edward B Chuong; Nels C Elde; Cédric Feschotte
Journal: Nat Rev Genet Date: 2016-11-21 Impact factor: 53.242

7. HIV enters cells via endocytosis and dynamin-dependent fusion with endosomes.

Authors: Kosuke Miyauchi; Yuri Kim; Olga Latinovic; Vladimir Morozov; Gregory B Melikyan
Journal: Cell Date: 2009-05-01 Impact factor: 41.582

8. Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories.

Authors: Niels Plath; Ora Ohana; Björn Dammermann; Mick L Errington; Dietmar Schmitz; Christina Gross; Xiaosong Mao; Arne Engelsberg; Claudia Mahlke; Hans Welzl; Ursula Kobalz; Anastasia Stawrakakis; Esperanza Fernandez; Robert Waltereit; Anika Bick-Sander; Eric Therstappen; Sam F Cooke; Veronique Blanquet; Wolfgang Wurst; Benedikt Salmen; Michael R Bösl; Hans-Peter Lipp; Seth G N Grant; Tim V P Bliss; David P Wolfer; Dietmar Kuhl
Journal: Neuron Date: 2006-11-09 Impact factor: 17.173

9. Structure of full-length HIV-1 CA: a model for the mature capsid lattice.

Authors: Barbie K Ganser-Pornillos; Anchi Cheng; Mark Yeager
Journal: Cell Date: 2007-10-05 Impact factor: 41.582

Review 10. The multifunctional Staufen proteins: conserved roles from neurogenesis to synaptic plasticity.

Authors: Jacki E Heraud-Farlow; Michael A Kiebler
Journal: Trends Neurosci Date: 2014-07-07 Impact factor: 13.837

8 in total

1. The Neuronal Gene Arc Encodes a Repurposed Retrotransposon Gag Protein that Mediates Intercellular RNA Transfer.

Authors: Elissa D Pastuzyn; Cameron E Day; Rachel B Kearns; Madeleine Kyrke-Smith; Andrew V Taibi; John McCormick; Nathan Yoder; David M Belnap; Simon Erlendsson; Dustin R Morado; John A G Briggs; Cédric Feschotte; Jason D Shepherd
Journal: Cell Date: 2018-01-11 Impact factor: 41.582

Arc - An endogenous neuronal retrovirus?

Review 1. New views of Arc, a master regulator of synaptic plasticity.

2. Arc: building a bridge from viruses to memory.

3. Deletion of Peg10, an imprinted gene acquired from a retrotransposon, causes early embryonic lethality.

4. Interaction of HIV-1 Gag with the clathrin-associated adaptor AP-2.

5. Internal initiation of translation of five dendritically localized neuronal mRNAs.

Review 6. Regulatory activities of transposable elements: from conflicts to benefits.

7. HIV enters cells via endocytosis and dynamin-dependent fusion with endosomes.

8. Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories.

9. Structure of full-length HIV-1 CA: a model for the mature capsid lattice.

Review 10. The multifunctional Staufen proteins: conserved roles from neurogenesis to synaptic plasticity.

1. The Neuronal Gene Arc Encodes a Repurposed Retrotransposon Gag Protein that Mediates Intercellular RNA Transfer.

Review 2. The Role of Transposable Elements of the Human Genome in Neuronal Function and Pathology.

3. Autophagy coupled to translation is required for long-term memory.

Review 4. Plasticity of Spine Structure: Local Signaling, Translation and Cytoskeletal Reorganization.

5. Developmental changes in plasticity, synaptic, glia, and connectivity protein levels in rat basolateral amygdala.

Review 6. Min pig skeletal muscle response to cold stress.

Review 7. Function of Drosophila Synaptotagmins in membrane trafficking at synapses.

Review 8. Social Networking of Quasi-Species Consortia drive Virolution via Persistence.