| Literature DB >> 28941866 |
J R García Garzón1, M de Arcocha Torres2, R Delgado-Bolton3, F Ceci4, S Alvarez Ruiz5, J Orcajo Rincón6, A P Caresia Aróztegui7, M J García Velloso8, A M García Vicente9.
Abstract
Positron emission tomography/computed tomography (PET/CT) with 68Ga-PSMA is a non-invasive diagnostic technique to image prostate cancer with increased prostate-specific membrane antigen (PSMA) expression. PSMA is a transmembrane protein present in all prostatic tissues. Increased PSMA expression is seen in several malignancies, although prostate cancer is the tumour where it presents higher concentrations. Almost all prostate adenocarcinomas show PSMA expression in most of lesions, primary and metastatic. Immunohistochemistry has demonstrated that the expression of PSMA increases in patients with de-differentiated, metastatic or hormone-refractory tumours. Moreover, the expression level of PSMA has a prognostic value for disease outcome. PET measures the three-dimensional distribution of 68Ga-PSMA, producing semi-quantitative images that allow for non-invasive assessment of PSMA expression.Entities:
Keywords: Cáncer de próstata; PET/CT; PET/TC; PSA; PSMA; Prognosis; Pronóstico; Prostate cancer; Recidiva; Relapse
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Year: 2017 PMID： 28941866 DOI： 10.1016/j.remn.2017.07.004
Source DB: PubMed Journal: Rev Esp Med Nucl Imagen Mol (Engl Ed) ISSN： 2253-8089