Literature DB >> 28941536

Rationale for Adjunctive Therapies for Pediatric Sepsis Induced Multiple Organ Failure.

Bradley S Podd1, Dennis W Simon1, Santiago Lopez2, Andrew Nowalk2, Rajesh Aneja1, Joseph A Carcillo3.   

Abstract

Adjunctive therapies have been proposed for use in at least 5 inflammation pathobiology phenotypes in pediatric sepsis-induced multiple organ failure. This article discusses host-pathogen interaction prototypes to facilitate understanding of the rationale for personalized therapy in these phenotypes. The article discusses the literature on adjunctive antiinflammatory and immune modulation therapies that, in addition to traditional organ support and infection source control, might be part of a personalized precision medicine approach to the reversal of each of these inflammatory pathobiology phenotypes.
Copyright © 2017 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Hyperleukocytosis; Immune paralysis; Macrophage activation syndrome; Sequential MOF; Thrombocytopenia-associated MOF

Mesh：

Year:  2017        PMID： 28941536      PMCID： PMC5663307          DOI： 10.1016/j.pcl.2017.06.007

Source DB:  PubMed          Journal:  Pediatr Clin North Am        ISSN： 0031-3955            Impact factor:   3.278


  105 in total

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Review 7.  Outcomes of previously healthy pediatric patients with fulminant sepsis-induced multisystem organ failure receiving therapeutic plasma exchange.

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8.  Expression of CTLA-4 (CD152) in peripheral blood T cells of children with influenza virus infection including encephalopathy in comparison with respiratory syncytial virus infection.

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2.  A Multicenter Network Assessment of Three Inflammation Phenotypes in Pediatric Sepsis-Induced Multiple Organ Failure.

Authors:  Joseph A Carcillo; Robert A Berg; David Wessel; Murray Pollack; Kathleen Meert; Mark Hall; Christopher Newth; John C Lin; Allan Doctor; Tom Shanley; Tim Cornell; Rick E Harrison; Athena F Zuppa; Ron W Reeder; Russell Banks; John A Kellum; Richard Holubkov; Daniel A Notterman; J Michael Dean
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3.  Therapeutic Plasma Exchange in Children With Thrombocytopenia-Associated Multiple Organ Failure: The Thrombocytopenia-Associated Multiple Organ Failure Network Prospective Experience.

Authors:  James D Fortenberry; Trung Nguyen; Jocelyn R Grunwell; Rajesh K Aneja; Derek Wheeler; Mark Hall; Geoffrey Fleming; Rod Tarrago; Sandra Buttram; Heidi Dalton; Yong Han; Kirk A Easley; Andrea Knezevic; Tian Dai; Matthew Paden; Joseph A Carcillo
Journal:  Crit Care Med       Date:  2019-03       Impact factor: 7.598

4.  Inhibition of XBP1 Alleviates LPS-Induced Cardiomyocytes Injury by Upregulating XIAP through Suppressing the NF-κB Signaling Pathway.

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5.  Clinical, laboratory features and prognosis of children receiving IgM-enriched immunoglobulin (3 days vs. 5 days) as adjuvant treatment for serious infectious disease in pediatric intensive care unit: a retrospective single-center experience (PIGMENT study).

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6.  Merging Pediatric Index of Mortality (a physiologic instability measure), lactate, and Systemic Inflammation Mortality Risk to better predict outcome in pediatric sepsis.

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  6 in total

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