Literature DB >> 28941456

PDX1: A Unique Pancreatic Master Regulator Constantly Changes Its Functions during Embryonic Development and Progression of Pancreatic Cancer.

T V Vinogradova1, E D Sverdlov.   

Abstract

Multifunctional activity of the PDX1 gene product is reviewed. The PDX1 protein is unique in that being expressed exclusively in the pancreas it exhibits various functional activities in this organ both during embryonic development and during induction and progression of pancreatic cancer. Hence, PDX1 belongs to the family of master regulators with multiple and often antagonistic functions.

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Year:  2017        PMID： 28941456     DOI： 10.1134/S000629791708003X

Source DB:  PubMed          Journal:  Biochemistry (Mosc)        ISSN： 0006-2979            Impact factor:   2.487


  9 in total

Review 1.  The role of lineage specifiers in pancreatic ductal adenocarcinoma.

Authors:  Soledad A Camolotto; Veronika K Belova; Eric L Snyder
Journal:  J Gastrointest Oncol       Date:  2018-12

2.  Heterogeneous Expression of Embryonal Development Master Regulator SOX9 in Patients with Pancreatic Cancer.

Authors:  L G Kondratyeva; I P Chernov; M V Zinovyeva; V I Egorov; E P Kopantzev; E D Sverdlov
Journal:  Dokl Biochem Biophys       Date:  2018-08-31       Impact factor: 0.788

3.  Development of thymic tumor in [LSL:KrasG12D; Pdx1-CRE] mice, an adverse effect associated with accelerated pancreatic carcinogenesis.

Authors:  Sophie Liot; Naïma El Kholti; Jonathan Balas; Laurent Genestier; Bernard Verrier; Ulrich Valcourt; Elise Lambert
Journal:  Sci Rep       Date:  2021-07-23       Impact factor: 4.379

Review 4.  Molecular Mechanism of Pancreatic β-Cell Failure in Type 2 Diabetes Mellitus.

Authors:  Hideaki Kaneto; Tomohiko Kimura; Masashi Shimoda; Atsushi Obata; Junpei Sanada; Yoshiro Fushimi; Taka-Aki Matsuoka; Kohei Kaku
Journal:  Biomedicines       Date:  2022-03-31

5.  Comprehensive network analysis of dysregulated genes revealed MNX1-AS1/hsa-miR-4697-3p/HOXB13 axis in ovarian cancer chemotherapy response.

Authors:  Anqi Wu; Jiaqi Liu; Xiaojun Zhang; Chenxi Niu; Guang Shu; Gang Yin
Journal:  Cancer Sci       Date:  2022-06-24       Impact factor: 6.518

Review 6.  The regulatory role of pioneer factors during cardiovascular lineage specification - A mini review.

Authors:  Javier E Sierra-Pagan; Daniel J Garry
Journal:  Front Cardiovasc Med       Date:  2022-08-23

Review 7.  Regulation of Pdx1 by oxidative stress and Nrf2 in pancreatic beta-cells.

Authors:  Sharon Baumel-Alterzon; Donald K Scott
Journal:  Front Endocrinol (Lausanne)       Date:  2022-09-15       Impact factor: 6.055

Review 8.  Hippo Signaling Pathway in Pancreas Development.

Authors:  Yifan Wu; Pauline Aegerter; Michael Nipper; Logan Ramjit; Jun Liu; Pei Wang
Journal:  Front Cell Dev Biol       Date:  2021-05-17

9.  Kinome Array Profiling of Patient-Derived Pancreatic Ductal Adenocarcinoma Identifies Differentially Active Protein Tyrosine Kinases.

Authors:  Justin F Creeden; Khaled Alganem; Ali S Imami; F Charles Brunicardi; Shi-He Liu; Rammohan Shukla; Tushar Tomar; Faris Naji; Robert E McCullumsmith
Journal:  Int J Mol Sci       Date:  2020-11-17       Impact factor: 5.923
  9 in total

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