Literature DB >> 28940813

Exosomes from human adipose-derived stem cells promote proliferation and migration of skin fibroblasts.

Eun Wook Choi1, Min Koo Seo1, Eun Young Woo1, Suk Hyung Kim1, Eun Joo Park1, Sue Kim1.   

Abstract

This study was undertaken to evaluate whether exosomes from human adipose-derived stem cells (ASC-exo) can stimulate the regeneration of human dermal fibroblasts (HDFs). Immunoblotting and FACS analyses showed that ASC-exo was positive for exosome markers. Fluorescence tracking revealed that the contents of ASC-exo were transferred into the HDFs. ASC-exo treatment also stimulated the proliferation and migration of HDFs in a dose-dependent manner. Similarly, the expression levels of genes involved in skin cell proliferation were increased by ASC-exo. Microarray analysis showed an enrichment of microRNAs that have regenerative function. We suggest that the ASC-exo can stimulate skin cell proliferation.
© 2017 The Authors. Experimental Dermatology Published by John Wiley & Sons Ltd.

Entities:  

Keywords:  extracellular vesicle; microRNA array; skin regeneration; wound healing

Mesh：

Substances：

Year:  2017        PMID： 28940813     DOI： 10.1111/exd.13451

Source DB:  PubMed          Journal:  Exp Dermatol        ISSN： 0906-6705            Impact factor:   3.960


  31 in total

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6.  Exosomes as Part of the Human Adipose-Derived Stem Cells Secretome- Opening New Perspectives for Cell-Free Regenerative Applications.

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7.  TBC1D3 regulates the payload and biological activity of extracellular vesicles that mediate tissue repair.

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Review 8.  Extracellular Vesicles as Potential Theranostic Platforms for Skin Diseases and Aging.

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Journal:  Pharmaceutics       Date:  2021-05-20       Impact factor: 6.321

Review 9.  Research Advances in the Application of Adipose-Derived Stem Cells Derived Exosomes in Cutaneous Wound Healing.

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Journal:  Ann Dermatol       Date:  2021-07-01       Impact factor: 1.444

Review 10.  Therapeutic applications of adipose cell-free derivatives: a review.

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