Henri G M J Bertrand1,2, Charlotte Sandersen3, Jennifer Murray1, Paul A Flecknell1,4. 1. Comparative Biology Centre, Newcastle University, Newcastle upon Tyne, UK. 2. Faculty of Veterinary Medicine, University of Liège, Liège, Belgium. 3. Faculty of Veterinary Medicine, Veterinary Anesthesia Department, University of Liege, Liege, Belgium. 4. Institute of Neurosciences, Newcastle University, Newcastle upon Tyne, UK.
Abstract
BACKGROUND: Chemical immobilization of non-human primates can be required to perform scientific or veterinary procedure with different invasiveness degrees. This preliminary study was undertaken to assess the clinical effects of a combination of alfaxalone, medetomidine and midazolam (AMM). METHODS: Seven rhesus macaques were chemically immobilized, for invasive veterinary procedures, with alfaxan 2 mg kg-1 , medetomidine 20 μg kg-1 and midazolam 0.3 mg kg-1 injected subcutaneously. RESULTS: The alfaxalone combination induced surgical anaesthesia, with a complete absence of response to noxious stimuli, for at least 20 minutes. The total duration of anaesthesia was 56 ± 7 minutes, and the administration of atipamezole, to partially reverse the combination effects, did not appear to alter the depth of anaesthesia. CONCLUSION: In conclusion, the AMM combination produced rapid onset general anaesthesia, following subcutaneous administration of a relatively low volume (0.28 mL/kg) of injectate.
BACKGROUND: Chemical immobilization of non-human primates can be required to perform scientific or veterinary procedure with different invasiveness degrees. This preliminary study was undertaken to assess the clinical effects of a combination of alfaxalone, medetomidine and midazolam (AMM). METHODS: Seven rhesus macaques were chemically immobilized, for invasive veterinary procedures, with alfaxan 2 mg kg-1 , medetomidine 20 μg kg-1 and midazolam 0.3 mg kg-1 injected subcutaneously. RESULTS: The alfaxalone combination induced surgical anaesthesia, with a complete absence of response to noxious stimuli, for at least 20 minutes. The total duration of anaesthesia was 56 ± 7 minutes, and the administration of atipamezole, to partially reverse the combination effects, did not appear to alter the depth of anaesthesia. CONCLUSION: In conclusion, the AMM combination produced rapid onset general anaesthesia, following subcutaneous administration of a relatively low volume (0.28 mL/kg) of injectate.
Authors: Rebecca L Erickson; Caroline E Blevins; Cecilia De Souza Dyer; James O Marx Journal: J Am Assoc Lab Anim Sci Date: 2018-12-20 Impact factor: 1.232
Authors: Brianna M Marion; Jeanean M Ghering; Benjamin C Dixon; Amanda M Casselman; Summer M Astleford; Charles E White; Philip A Bowling Journal: Comp Med Date: 2022-06-30 Impact factor: 1.565
Authors: Kelsey R Finnie; Carissa P Jones; William D Dupont; Kenneth J Salleng; Katherine A Shuster Journal: J Am Assoc Lab Anim Sci Date: 2020-07-21 Impact factor: 1.232
Authors: M A Basso; S Frey; K A Guerriero; B Jarraya; S Kastner; K W Koyano; D A Leopold; K Murphy; C Poirier; W Pope; A C Silva; G Tansey; L Uhrig Journal: Neuroimage Date: 2020-12-24 Impact factor: 6.556