S Hotier1,2,3,4,5,6, F Leroy7, J Boisgontier1,2,3, C Laidi1,2,3,5, J-F Mangin8, R Delorme3,9,10, F Bolognani11, C Czech11, C Bouquet11, E Toledano12, M Bouvard3,13, J Petit3,5, M Mishchenko14,15, M-A d'Albis1,2,3,5, D Gras3,14,16, A Gaman2,3,5, I Scheid2,3,5,9, M Leboyer2,3,5,6, T Zalla3,14, J Houenou1,2,3,5,6. 1. UNIACT, Psychiatry Team, Neurospin Neuroimaging Platform, CEA Saclay, Gif-Sur-Yvette, France. 2. INSERM U955, Mondor Institute for Biomedical Research, Team 15, Translational Psychiatry, Créteil, France. 3. Fondation Fondamental, Créteil, France. 4. Psychiatry Department, Charles Nicolle University Hospital, Rouen, France. 5. DHU PePSY, Department of Psychiatry, Assistance Publique-Hôpitaux de Paris (AP-HP), Mondor University Hospitals, Créteil, France. 6. Faculty of Medicine, Paris East University, Créteil, France. 7. INSERM, U992, UNICOG, NeuroSpin Neuroimaging Platform, University Paris Saclay, CEA Saclay, Gif-Sur-Yvette, France. 8. UNATI, Neurospin Neuroimaging Platform, CEA Saclay, Gif-Sur-Yvette, France. 9. Child and Adolescent Psychiatry Department, Assistance Publique-Hôpitaux de Paris (AP-HP), Robert Debré Hospital, Paris, France. 10. Institut Pasteur, Human Genetics and Cognitive Functions Unit, Paris, France. 11. Neuroscience, Ophthalmology, and Rare Diseases (NORD), Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland. 12. Institut Roche, Roche Pharmaceuticals, Boulogne-Billancourt, France. 13. Children and Adolescent Psychiatry Department, Bordeaux University Hospital, Bordeaux, France. 14. Jean Nicod Institute, Centre National de la Recherche Scientifique, Ecole Normale Supeérieure, PSL, Research University, Paris, France. 15. Laboratory of Psychopathology and Health Processes (EA 4057), Paris Descartes University, Sorbonne Paris Cité, France. 16. Laboratoire de Linguistique Formelle, CNRS, Paris Diderot University, Paris, France.
Abstract
OBJECTIVE: The posterior superior temporal sulcus (pSTS) plays a critical role in the 'social brain'. Its neurodevelopment and relationship with the social impairment in autism spectrum disorders (ASD) are not well understood. We explored the relationship between social cognition and the neurodevelopment of the pSTS in ASD. METHOD: We included 44 adults with high-functioning ASD and 36 controls. We assessed their performances on the 'Reading the mind in the eyes' test (for 34 of 44 subjects with ASD and 30 of 36 controls), their fixation time on the eyes with eye tracking (for 35 of 44 subjects with ASD and 30 of 36 controls) and the morphology of the caudal branches of the pSTS (length and depth), markers of the neurodevelopment, with structural MRI. RESULTS: The right anterior caudal ramus of the pSTS was significantly longer in patients with ASD compared with controls (52.6 mm vs. 38.3 mm; P = 1.4 × 10-3 ; Cohen's d = 0.76). Its length negatively correlated with fixation time on the eyes (P = 0.03) in the ASD group and with the 'Reading the mind in the eyes' test scores in both groups (P = 0.03). CONCLUSION: Our findings suggest that the neurodevelopment of the pSTS is related to the ASD social impairments.
OBJECTIVE: The posterior superior temporal sulcus (pSTS) plays a critical role in the 'social brain'. Its neurodevelopment and relationship with the social impairment in autism spectrum disorders (ASD) are not well understood. We explored the relationship between social cognition and the neurodevelopment of the pSTS in ASD. METHOD: We included 44 adults with high-functioning ASD and 36 controls. We assessed their performances on the 'Reading the mind in the eyes' test (for 34 of 44 subjects with ASD and 30 of 36 controls), their fixation time on the eyes with eye tracking (for 35 of 44 subjects with ASD and 30 of 36 controls) and the morphology of the caudal branches of the pSTS (length and depth), markers of the neurodevelopment, with structural MRI. RESULTS: The right anterior caudal ramus of the pSTS was significantly longer in patients with ASD compared with controls (52.6 mm vs. 38.3 mm; P = 1.4 × 10-3 ; Cohen's d = 0.76). Its length negatively correlated with fixation time on the eyes (P = 0.03) in the ASD group and with the 'Reading the mind in the eyes' test scores in both groups (P = 0.03). CONCLUSION: Our findings suggest that the neurodevelopment of the pSTS is related to the ASD social impairments.
Authors: Danielle A Baribeau; Annie Dupuis; Tara A Paton; Christopher Hammill; Stephen W Scherer; Russell J Schachar; Paul D Arnold; Peter Szatmari; Rob Nicolson; Stelios Georgiades; Jennifer Crosbie; Jessica Brian; Alana Iaboni; Azadeh Kushki; Jason P Lerch; Evdokia Anagnostou Journal: Transl Psychiatry Date: 2019-02-04 Impact factor: 6.222
Authors: Giorgio Di Lorenzo; Assia Riccioni; Michele Ribolsi; Martina Siracusano; Paolo Curatolo; Luigi Mazzone Journal: Front Psychiatry Date: 2020-11-24 Impact factor: 4.157
Authors: Collins Opoku-Baah; Adriana M Schoenhaut; Sarah G Vassall; David A Tovar; Ramnarayan Ramachandran; Mark T Wallace Journal: J Assoc Res Otolaryngol Date: 2021-05-20