Literature DB >> 28939179

Heart dose associated with overall survival in locally advanced NSCLC patients treated with hypofractionated chemoradiotherapy.

Barbara Stam1, Erik van der Bijl1, Judi van Diessen1, Maddalena M G Rossi1, Angela Tijhuis1, José S A Belderbos1, Eugène Damen1, Jan-Jakob Sonke2.   

Abstract

Association of heart dose and overall survival was investigated in a cohort including 469 locally-advanced NSCLC patients receiving daily low-dose hypofractionated chemo-radiotherapy. Significant associations were found over a range of dose parameters. Multivariate analysis showed significant associations of heart_V2Gy:HR=1.007%-1 (95% CI:1.002-1.013; p=0.006), age:HR=1.026year-1 (1.011-1.042; p=0.001) and GTV volume:HR=1.001cc-1 (1.000-1.002; p=0.006) with overall survival.
Copyright © 2017 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Chemoradiation; Heart toxicity; Locally advanced non-small cell lung cancer

Mesh：

Year:  2017        PMID： 28939179     DOI： 10.1016/j.radonc.2017.09.004

Source DB:  PubMed          Journal:  Radiother Oncol        ISSN： 0167-8140            Impact factor:   6.280


  12 in total

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Review 6.  Hypofractionation and Stereotactic Body Radiation Therapy in Inoperable Locally Advanced Non-small Cell Lung Cancer.

Authors:  Mikel Rico; Maribel Martínez; Maitane Rodríguez; Lombardo Rosas; Andrea Barco; Enrique Martínez
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7.  Association of lung and heart dose with survival in patients with non-small cell lung cancer underwent volumetric modulated arc therapy.

Authors:  Lanxiao Shen; Cong Liu; Juebin Jin; Ce Han; Yongqiang Zhou; Xiaomin Zheng; Changfei Gong; Mengfeng Chen; Congying Xie; Xiance Jin
Journal:  Cancer Manag Res       Date:  2019-07-03       Impact factor: 3.989

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9.  Why aren't we getting consistent results for heart dose and mortality during thoracic radiotherapy?

Authors:  Jianxin Xue; You Lu; Feng-Ming Spring Kong
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10.  Are patients with stage III non-small cell lung cancer treated with chemoradiotherapy at risk for cardiac events? Results from a retrospective cohort study.

Authors:  Juliette Degens; D De Ruysscher; Ruud Houben; Bastiaan Kietselaer; Gerben Bootsma; Lizza Hendriks; Ellen Huijbers; Annemie Schols; Anne-Marie C Dingemans
Journal:  BMJ Open       Date:  2020-09-28       Impact factor: 2.692
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