Mahmut Yesin1, Macit Kalçık2, Metin Çağdaş3, Yavuz Karabağ3, İbrahim Rencüzoğulları3, Mustafa Ozan Gürsoy4, Süleyman Çağan Efe5, Süleyman Karakoyun3. 1. Department of Cardiology, Kars Harakani State Hospital, Kars, Turkey. Electronic address: mahmutyesin@yahoo.com. 2. Department of Cardiology, Hitit University Faculty of Medicine, Çorum, Turkey. 3. Department of Cardiology, Kars Kafkas University, Faculty of Medicine, Kars, Turkey. 4. Department of Cardiology, Gaziemir State Hospital, İzmir, Turkey. 5. Department of Cardiology, Ağrı State Hospital, Ağrı, Turkey.
Abstract
BACKGROUND: Fragmented QRS (fQRS) has been shown to be a marker of local myocardial conduction abnormalities, cardiac fibrosis in previous studies. It was also reported to be a predictor of sudden cardiac death and increased morbidity and mortality in selected populations. However, there is no study investigating the role of fQRS in the development of atrial fibrillation in patients with ST segment elevation myocardial infarction (STEMI). In this study we aimed to investigate the relationship between the presence of fQRS after primary percutaneous coronary intervention (pPCI) and in-hospital development of new-onset atrial fibrilation (AF) in patients with STEMI. MATERIAL AND METHODS: This study enrolled 171 patients undergoing pPCI for STEMI. Among these patients 24 patients developed AF and the remaining 147 patients were designated as the controls. All clinical, demographical and laboratory parameters were entered into a dataset and compared between AF group and the controls. RESULTS: The presence of fQRS was higher in the AF group than in the controls (P=0.001). Diabetes mellitus and fQRS was significantly more common in the AF group (P=0.003 and P=0.001 respectively) Logistic regression analysis demonstrated that the presence of fQRS was the independent determinant of AF (OR: 3.243, 95% CI 1.016-10.251, P=0.042). CONCLUSIONS: Increased atrial fibrillation was observed more frequently in STEMI patients with fQRS than in patients without fQRS. fQRS is an important determinant of AF in STEMI after pPCI.
BACKGROUND: Fragmented QRS (fQRS) has been shown to be a marker of local myocardial conduction abnormalities, cardiac fibrosis in previous studies. It was also reported to be a predictor of sudden cardiac death and increased morbidity and mortality in selected populations. However, there is no study investigating the role of fQRS in the development of atrial fibrillation in patients with ST segment elevation myocardial infarction (STEMI). In this study we aimed to investigate the relationship between the presence of fQRS after primary percutaneous coronary intervention (pPCI) and in-hospital development of new-onset atrial fibrilation (AF) in patients with STEMI. MATERIAL AND METHODS: This study enrolled 171 patients undergoing pPCI for STEMI. Among these patients 24 patients developed AF and the remaining 147 patients were designated as the controls. All clinical, demographical and laboratory parameters were entered into a dataset and compared between AF group and the controls. RESULTS: The presence of fQRS was higher in the AF group than in the controls (P=0.001). Diabetes mellitus and fQRS was significantly more common in the AF group (P=0.003 and P=0.001 respectively) Logistic regression analysis demonstrated that the presence of fQRS was the independent determinant of AF (OR: 3.243, 95% CI 1.016-10.251, P=0.042). CONCLUSIONS: Increased atrial fibrillation was observed more frequently in STEMI patients with fQRS than in patients without fQRS. fQRS is an important determinant of AF in STEMI after pPCI.
Authors: Tapio Hellman; Markus Hakamäki; Roosa Lankinen; Niina Koivuviita; Jussi Pärkkä; Petri Kallio; Tuomas Kiviniemi; K E Juhani Airaksinen; Mikko J Järvisalo; Kaj Metsärinne Journal: BMC Cardiovasc Disord Date: 2020-10-07 Impact factor: 2.298