Literature DB >> 28939156

Immunosurveillance of Malignant Cells with Complex Karyotypes.

Alejandro López-Soto1, Segundo Gonzalez2, Carlos López-Larrea3, Guido Kroemer4.   

Abstract

A wide array of cell-intrinsic surveillance mechanisms maintains the homeostasis of dividing cells and the integrity of the genome. Accumulating evidence also supports a role for cell-extrinsic mechanisms. Among them, the immune system, together with cell-autonomous checkpoint processes, eliminates cells that harbor unbalanced karyotypes generated by mitotic defects.
Copyright © 2017 Elsevier Ltd. All rights reserved.

Keywords:  aneuploidy; cancer immunotherapy; hyperploidy; immune checkpoint; immunosurveillance; somatic copy-number alteration

Mesh：

Year:  2017        PMID： 28939156     DOI： 10.1016/j.tcb.2017.09.001

Source DB:  PubMed          Journal:  Trends Cell Biol        ISSN： 0962-8924            Impact factor:   20.808


  7 in total

1.  Molecular and clinicopathological analysis revealed an immuno-checkpoint inhibitor as a potential therapeutic target in a subset of high-grade myxofibrosarcoma.

Authors:  Atsushi Yamashita; Yoshiyuki Suehara; Takuo Hayashi; Tatsuya Takagi; Daisuke Kubota; Keita Sasa; Nobuhiko Hasegawa; Muneaki Ishijima; Takashi Yao; Tsuyoshi Saito
Journal:  Virchows Arch       Date:  2022-06-15       Impact factor: 4.535

2.  Genomic instability genes in lung and colon adenocarcinoma indicate organ specificity of transcriptomic impact on Copy Number Alterations.

Authors:  Chinthalapally V Rao; Chao Xu; Yuting Zhang; Adam S Asch; Hiroshi Y Yamada
Journal:  Sci Rep       Date:  2022-07-11       Impact factor: 4.996

3.  Immune effectors responsible for the elimination of hyperploid cancer cells.

Authors:  Fernando Aranda; Kariman Chaba; Norma Bloy; Pauline Garcia; Chloé Bordenave; Isabelle Martins; Gautier Stoll; Antoine Tesniere; Guido Kroemer; Laura Senovilla
Journal:  Oncoimmunology       Date:  2018-05-21       Impact factor: 8.110

4.  Generation and Isolation of Cell Cycle-arrested Cells with Complex Karyotypes.

Authors:  Ruoxi W Wang; Emily MacDuffie; Stefano Santaguida
Journal:  J Vis Exp       Date:  2018-04-13       Impact factor: 1.355

5.  Status of programmed death-ligand 1 expression in sarcomas.

Authors:  Hyung Kyu Park; Mingi Kim; Minjung Sung; Seung Eun Lee; Yu Jin Kim; Yoon-La Choi
Journal:  J Transl Med       Date:  2018-11-06       Impact factor: 5.531

6.  Survival-Critical Genes Associated with Copy Number Alterations in Lung Adenocarcinoma.

Authors:  Chinthalapally V Rao; Chao Xu; Mudassir Farooqui; Yuting Zhang; Adam S Asch; Hiroshi Y Yamada
Journal:  Cancers (Basel)       Date:  2021-05-25       Impact factor: 6.639

7.  Polyploidy Spectrum Correlates with Immunophenotype and Shapes Hepatocellular Carcinoma Recurrence Following Liver Transplantation.

Authors:  Liang Zhang; Zhentao Yang; Shiyu Zhang; Ke Zhou; Wu Zhang; Sunbin Ling; Ruiqi Sun; Hong Tang; Xue Wen; Xiaowen Feng; Penghong Song; Xiao Xu; Haiyang Xie; Shusen Zheng
Journal:  J Inflamm Res       Date:  2022-01-11
  7 in total

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