Hua Zhong1, Zhihao Shu2, Yuqing Zhou2, Yao Lu3, Bin Yi4, Xiaohong Tang2, Chan Liu3, Qihong Deng4, Hong Yuan5, Zhijun Huang6. 1. Department of Cardiology, Xiangya Hospital, Central South University, Changsha, China. 2. Center of Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, China; Department of Cardiology, The Third Xiangya Hospital, Central South University, Changsha, China. 3. Center of Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, China. 4. Institute of Environmental Health, Central South University, Changsha, China. 5. Center of Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, China; Department of Cardiology, The Third Xiangya Hospital, Central South University, Changsha, China; Institute of Environmental Health, Central South University, Changsha, China. 6. Center of Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, China; Institute of Environmental Health, Central South University, Changsha, China. Electronic address: huangzj@csu.edu.cn.
Abstract
BACKGROUND: The relationship between air pollution and stroke is conflicting. This study was conducted to document the relationship between daily changes in atmospheric pollutants and hospital emergency room visits (ERVs) for stroke. METHODS: Data of daily hospital ERVs for stroke and atmospheric pollutants in Changsha city between 2008 and 2009 were collected. Using a time-stratified bidirectional case-crossover design, we analyzed the association between atmospheric pollutants and stroke incidence in 4 seasons. RESULTS: In the single-pollutant model, we found changes in sulfur dioxide (SO2), nitrogen dioxide (NO2), and particulate matters (PM10) were significantly associated with cerebral hemorrhage and cerebral infarction (P < .05) in lags of 0-2 days in autumn. A 10-µg/m3 increase in SO2 in autumn was significantly associated with ERVs for both cerebral hemorrhage (odds ratio [OR], 1.166; 95% confidence interval [CI], 1.012-1.343) and cerebral infarction (OR, 1.214; 95% CI, 1.018-1.448). NO2 in autumn was significantly associated with ERVs for cerebral hemorrhage and infarction with OR = 1.162 (95% CI, 1.005-1.344) and OR = 1.137 (95% CI, 1.011-1.279), respectively. PM10 in autumn was significantly associated with ERVs for cerebral hemorrhage and infarction with OR = 1.147 (95% CI, 1.045-1.259) and OR = 1.091 (95% CI, 1.019-1.168), respectively. Results of the multipollutant model showed that in autumn after PM10 and NO2 adjustment, only a 10-µg/m3 increase in SO2 was significantly associated with ERVs for cerebral infarction (OR, 1.158; 95% CI, 1.006-1.333; P < .05). SO2, NO2, and PM10 were not associated with ERVs for cerebral hemorrhage (P > .05). CONCLUSIONS: This study demonstrates that the change in atmospheric SO2 levels in Changsha is significantly associated with the stroke incidence in autumn.
BACKGROUND: The relationship between air pollution and stroke is conflicting. This study was conducted to document the relationship between daily changes in atmospheric pollutants and hospital emergency room visits (ERVs) for stroke. METHODS: Data of daily hospital ERVs for stroke and atmospheric pollutants in Changsha city between 2008 and 2009 were collected. Using a time-stratified bidirectional case-crossover design, we analyzed the association between atmospheric pollutants and stroke incidence in 4 seasons. RESULTS: In the single-pollutant model, we found changes in sulfur dioxide (SO2), nitrogen dioxide (NO2), and particulate matters (PM10) were significantly associated with cerebral hemorrhage and cerebral infarction (P < .05) in lags of 0-2 days in autumn. A 10-µg/m3 increase in SO2 in autumn was significantly associated with ERVs for both cerebral hemorrhage (odds ratio [OR], 1.166; 95% confidence interval [CI], 1.012-1.343) and cerebral infarction (OR, 1.214; 95% CI, 1.018-1.448). NO2 in autumn was significantly associated with ERVs for cerebral hemorrhage and infarction with OR = 1.162 (95% CI, 1.005-1.344) and OR = 1.137 (95% CI, 1.011-1.279), respectively. PM10 in autumn was significantly associated with ERVs for cerebral hemorrhage and infarction with OR = 1.147 (95% CI, 1.045-1.259) and OR = 1.091 (95% CI, 1.019-1.168), respectively. Results of the multipollutant model showed that in autumn after PM10 and NO2 adjustment, only a 10-µg/m3 increase in SO2 was significantly associated with ERVs for cerebral infarction (OR, 1.158; 95% CI, 1.006-1.333; P < .05). SO2, NO2, and PM10 were not associated with ERVs for cerebral hemorrhage (P > .05). CONCLUSIONS: This study demonstrates that the change in atmospheric SO2 levels in Changsha is significantly associated with the stroke incidence in autumn.