Payam Dehghani1, Andrea Lavoie2, Shahar Lavi3, Jennifer J Crawford2, Sebastian Harenberg2, Rodney H Zimmermann2, Jeff Booker2, Sheila Kelly2, Warren J Cantor4, Shamir R Mehta5, Akshay Bagai6, Shaun G Goodman6, Asim N Cheema6. 1. Prairie Vascular Research Network and Regina Qu'Appelle Health Region, University of Saskatchewan, Regina, Saskatchewan, Canada. Electronic address: pdehghani@mac.com. 2. Prairie Vascular Research Network and Regina Qu'Appelle Health Region, University of Saskatchewan, Regina, Saskatchewan, Canada. 3. London Health Sciences, University of London, London, Ontario, Canada. 4. Southlake Regional Health Centre, University of Toronto, Newmarket, Ontario, Canada. 5. Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada. 6. Terrence Donnelly Heart Centre, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
Abstract
OBJECTIVES:Patients undergoing PCI early afterfibrinolytic therapy are at high risk for both thrombotic and bleeding complications. We sought to assess the pharmacodynamic effects of ticagrelor versus clopidogrel in the fibrinolytic-treated STEMI patients undergoing early PCI. METHODS AND RESULTS:Patients undergoing PCI within 24 hours of tenecteplase (TNK), aspirin, and clopidogrel for STEMI were randomized to receive additional clopidogrel 300 mg followed by 75 mg daily or ticagrelor 180 mg followed by 90 mg twice daily. The platelet reactivity units (PRU) were measured with the VerifyNow Assay before study drug administration (baseline) at 4 and 24 hours post-PCI. The primary end point was PRU ≤208 at 4 hours. A total of 140 patients (74 in ticagrelor and 66 in clopidogrel group) were enrolled. The mean PRU values at baseline were similar for the 2 groups (257.8±52.9 vs 259.5±56.7, P=.85, respectively). Post-PCI, patients on ticagrelor, compared to those on clopidogrel, had significantly lower PRU at 4 hours (78.7±88 vs 193.6±86.5, respectively, P<.001) and at 24 hours (34.5±35.0 and 153.5±75.5, respectively, P<.001). The primary end point was observed in 87.8% (n=65) in the ticagrelor-treated patients compared to 57.6% (n=38) of clopidogrel-treated patients, P<.001. CONCLUSION: Fibrinolysis-treated STEMI patients who received clopidogrel and aspirin at the time of fibrinolysis and were undergoing early PCI frequently had PRU >208. In this high-risk population, ticagrelor provides more prompt and potent platelet inhibition compared with clopidogrel (Funded by Astra Zeneca; NCT01930591, https://clinicaltrials.gov/ct2/show/NCT01930591).
RCT Entities:
OBJECTIVES:Patients undergoing PCI early after fibrinolytic therapy are at high risk for both thrombotic and bleeding complications. We sought to assess the pharmacodynamic effects of ticagrelor versus clopidogrel in the fibrinolytic-treated STEMI patients undergoing early PCI. METHODS AND RESULTS:Patients undergoing PCI within 24 hours of tenecteplase (TNK), aspirin, and clopidogrel for STEMI were randomized to receive additional clopidogrel 300 mg followed by 75 mg daily or ticagrelor 180 mg followed by 90 mg twice daily. The platelet reactivity units (PRU) were measured with the VerifyNow Assay before study drug administration (baseline) at 4 and 24 hours post-PCI. The primary end point was PRU ≤208 at 4 hours. A total of 140 patients (74 in ticagrelor and 66 in clopidogrel group) were enrolled. The mean PRU values at baseline were similar for the 2 groups (257.8±52.9 vs 259.5±56.7, P=.85, respectively). Post-PCI, patients on ticagrelor, compared to those on clopidogrel, had significantly lower PRU at 4 hours (78.7±88 vs 193.6±86.5, respectively, P<.001) and at 24 hours (34.5±35.0 and 153.5±75.5, respectively, P<.001). The primary end point was observed in 87.8% (n=65) in the ticagrelor-treated patients compared to 57.6% (n=38) of clopidogrel-treated patients, P<.001. CONCLUSION: Fibrinolysis-treated STEMI patients who received clopidogrel and aspirin at the time of fibrinolysis and were undergoing early PCI frequently had PRU >208. In this high-risk population, ticagrelor provides more prompt and potent platelet inhibition compared with clopidogrel (Funded by Astra Zeneca; NCT01930591, https://clinicaltrials.gov/ct2/show/NCT01930591).
Authors: Andrew Yang; Quin Pon; Andrea Lavoie; Jennifer J Crawford; Sebastian Harenberg; Rodney H Zimmermann; Jeff Booker; Sheila Kelly; Shahar Lavi; Warren J Cantor; Shamir R Mehta; Akshay Bagai; Shaun G Goodman; Asim N Cheema; Payam Dehghani Journal: J Thromb Thrombolysis Date: 2018-02 Impact factor: 2.300
Authors: Otavio Berwanger; Jose C Nicolau; Antonio C Carvalho; Lixin Jiang; Shaun G Goodman; Stephen J Nicholls; Alexander Parkhomenko; Oleg Averkov; Carlos Tajer; Germán Malaga; Jose F K Saraiva; Francisco A Fonseca; Fábio A De Luca; Helio P Guimaraes; Pedro G M de Barros E Silva; Lucas P Damiani; Denise M Paisani; Camila M R Lasagno; Carolina T Candido; Nanci Valeis; Diogo D F Moia; Leopoldo S Piegas; Christopher B Granger; Harvey D White; Renato D Lopes Journal: JAMA Cardiol Date: 2018-05-01 Impact factor: 14.676
Authors: Marco Ranucci; Tommaso Aloisio; Umberto Di Dedda; Lorenzo Menicanti; Carlo de Vincentiis; Ekaterina Baryshnikova Journal: PLoS One Date: 2019-11-27 Impact factor: 3.240
Authors: Robert C Welsh; Jay S Shavadia; Yinggan Zheng; Benjamin D Tyrrell; Raymond Leung; Kevin R Bainey Journal: Clin Cardiol Date: 2021-08-18 Impact factor: 2.882