Literature DB >> 2893736

Pharmacokinetics of diazepam and four 3-hydroxy-benzodiazepines in the cat.

J J Driessen1, T B Vree, F Van de Pol, J F Crul.   

Abstract

Biotransformation and elimination of diazepam and four 3-hydroxy-benzodiazepines after i.v. injection in anaesthetized cats were investigated. Decay of plasma concentration of 3-hydroxy-benzodiazepines was slow and plasma concentrations of their glucuronides were lower than of unchanged parent compounds. In the urine, very low excretion rates of all investigated benzodiazepines were found during the first eight hours. It is concluded that cats poorly glucuronidate 3-dydroxy-benzodiazepines.

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Year:  1987        PMID： 2893736     DOI： 10.1007/BF03189901

Source DB:  PubMed          Journal:  Eur J Drug Metab Pharmacokinet        ISSN： 0378-7966            Impact factor:   2.441


  8 in total

Review 1.  Pharmacology of benzodiazepines: laboratory and clinical correlations.

Authors:  G Zbinden; L O Randall
Journal:  Adv Pharmacol       Date:  1967

2.  The biotransformation of [14C]lormetazepam in dogs, rabbits, rats and rhesus monkeys.

Authors:  B C Mayo; D R Hawkins; M Hümpel; L F Chasseaud; R Girkin
Journal:  Xenobiotica       Date:  1980-06       Impact factor: 1.908

3.  Simultaneous determination of diazepam and its metabolies N-desmethyldiazepam, oxydiazepam and oxazepam in plasma and urine of man and dog by means of high-performance liquid chromatography.

Authors:  T B Vree; A M Baars; Y A Hekster; E van der Kleijn; W J O'Reilly
Journal:  J Chromatogr       Date:  1979-04-11

4.  Significance of apparent half-lives of a metabolite with a higher elimination rate than its parent drug.

Authors:  T B Vree; C A Hekster; E van der Kleijn
Journal:  Drug Intell Clin Pharm       Date:  1982-02

5.  Pharmacokinetics of diazepam and nordiazepam in the cat.

Authors:  S Cotler; J H Gustafson; W A Colburn
Journal:  J Pharm Sci       Date:  1984-03       Impact factor: 3.534

6.  Lorazepam: glucuronide formation in the cat.

Authors:  R T Schillings; S F Sisenwine; M H Schwartz; H W Ruelius
Journal:  Drug Metab Dispos       Date:  1975 Mar-Apr       Impact factor: 3.922

7.  Comparative metabolism of lorazepam in man and four animal species.

Authors:  H W Ruelius
Journal:  J Clin Psychiatry       Date:  1978-10       Impact factor: 4.384

8.  Species-related differences in the stereoselective glucuronidation of oxazepam.

Authors:  S F Sisenwine; C O Tio; F V Hadley; A L Liu; H B Kimmel; H W Ruelius
Journal:  Drug Metab Dispos       Date:  1982 Nov-Dec       Impact factor: 3.922
  8 in total

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